Scleromyositis – The new frontier

IF 7 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-03-06 DOI:10.1016/j.berh.2026.102126

Marie Hudson , Yves Troyanov , Océane Landon-Cardinal

引用次数: 0

Abstract

In this review, we examine the clinical, serological, and pathological characteristics of muscle involvement in systemic sclerosis (SSc) and delineate features that distinguish it from other autoimmune myositis (AIM). We posit that muscle involvement in SSc represents a primary disease manifestation rather than an overlap between two conditions, reflecting shared pathogenic mechanisms with other organ manifestations in SSc. On this basis, we propose the term scleromyositis (SM). We further propose a conceptual framework for the pathogenesis of SM, review current knowledge on its prognosis and management, and present illustrative cases that highlight features that are unique to this entity. We aim to increase awareness of this under-recognized entity, highlight its broad spectrum and encourage a more consistent use of the term scleromyositis.

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硬化肌炎——新领域。

在这篇综述中，我们研究了系统性硬化症（SSc）肌肉受累的临床、血清学和病理特征，并描述了将其与其他自身免疫性肌炎（AIM）区分开来的特征。我们假设肌肉受累在SSc中代表了一种原发性疾病表现，而不是两种疾病之间的重叠，反映了SSc与其他器官表现的共同致病机制。在此基础上，我们提出硬化肌炎（SM）一词。我们进一步提出了SM发病机制的概念框架，回顾了目前关于其预后和管理的知识，并提出了突出该实体独特特征的说明案例。我们的目标是提高对这种未被充分认识的实体的认识，强调其广泛性，并鼓励更一致地使用“硬化肌炎”一词。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.