Neuronal VIP shapes intestinal stem cell activity and mucosal immunity.

IF 20.4 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2026-03-05 DOI:10.1016/j.stem.2026.02.001

Camilla Anastasio,Lucie Peduto

引用次数: 0

Abstract

Intestinal homeostasis and regeneration rely on intestinal stem cells (ISCs). Li et al.1 identified neuronal vasoactive intestinal peptide (VIP) as a brake on ISCs through VIPR1 to limit regeneration. In Nature Immunology, Jakob et al. and Pirzgalska et al. further showed that VIP-VIPR1 signaling restrains secretory lineage expansion and balances immune responses.2,3.

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神经元VIP影响肠干细胞活性和粘膜免疫。

肠道内稳态和再生依赖于肠道干细胞（ISCs）。Li等人1发现神经元血管活性肠肽（VIP）通过VIPR1抑制ISCs再生。Jakob et al.和Pirzgalska et al.在Nature Immunology上进一步表明，VIP-VIPR1信号传导抑制分泌谱系扩张并平衡免疫反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.