Aswen Sriranganathan, Jacob Stasso, Rafael N Miranda, Tina Felfeli
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引用次数: 0
Abstract
Purpose: To estimate the incidence and prevalence of noninfectious uveitis (NIU).
Methods: A systematic literature search was conducted of electronic databases including Ovid MEDLINE, Embase, and Scopus from 2020 to September 2025. A random-effects meta-analysis pooled incidence and prevalence data across various demographic and comorbid contexts.
Results: From 15,172 initial studies, 106 were included. The pooled prevalence of NIU was 131.6 (95% CI 28.1-613.9) for adults and 27.4 (95% CI 6.3-118.3) for pediatrics per 100,000 persons. Pooled incidence of NIU was 204.4 (95% CI 0.0-438.9) for adults and 16.0 (95% CI 6.5-25.6) for pediatrics per 100,000 person-years. Increased incidence and prevalence of NIU were seen in populations of Juvenile idiopathic arthritis (JIA), undifferentiated spondyloarthritis (SpA), psoriatic arthritis (PsA), ankylosing spondylitis (AS), and Behcet disease (BD). The prevalence of NIU in JIA was 129.2 (95% CI 94.2-174.7) per 1,000 persons and incidence was 22.4 (95% CI 2.5-42.4) per 1,000 person-years. The prevalence and incidence of NIU in SpA was 153.5 (95% CI 122.0-191.4) per 1,000 persons and 33.5 (95% CI 0.0-69.2) per 1,000 person-years, respectively. The prevalence and incidence of NIU in PsA was 27.3 (95% CI 18.1-41.2) per 1,000 persons and 13.1 (95% CI 0.0-32.5) per 1,000 person-years, respectively. The prevalence of NIU in AS and BD was 183.5 (95% CI 137.8-240.1) and 148.6 (95% CI 17.6-629.9) per 1,000 persons, respectively.
Conclusion: NIU incidence and prevalence were higher in adults than in children, and in populations with specific conditions such as JIA and AS.
目的：了解非感染性葡萄膜炎（NIU）的发病率和流行情况。方法：系统检索Ovid Medline、Embase、Scopus等电子数据库2020 - 2025年9月的文献。随机效应荟萃分析汇集了不同人口统计学和共病背景下的发病率和患病率数据。结果：在15,172项初始研究中，106项被纳入。每10万人中，成人和儿科的总患病率分别为131.6 （95% CI 28.1-613.9）和27.4 （95% CI 6.3-118.3）。成人和儿科的合并发病率分别为每10万人年204.4例（95% CI 0-438.9）和16.0例（95% CI 6.5-25.6）。在青少年特发性关节炎（JIA）、未分化性脊柱炎（SpA）、银屑病关节炎（PsA）、强直性脊柱炎（AS）和白塞病（BD）人群中，NIU的发病率和患病率均有所增加。JIA的牛牛患病率为每1000人129.2例（95% CI 94.2-174.7），发病率为每1000人年22.4例（95% CI 2.5-42.4）。SpA地区的NIU患病率和发病率分别为每1000人153.5 （95% CI 122.0-191.4）和每1000人年33.5 （95% CI 0.0-69.2）。PsA中NIU的患病率和发病率分别为每1000人27.3例（95% CI 18.1-41.2）和每1000人年13.1例（95% CI 0.0-32.5）。AS和BD的发病率分别为每1000人183.5例（95% CI 137.8-240.1）和148.6例（95% CI 17.6-629.9）。结论：成人中NIU的发病率和患病率高于儿童，在JIA和AS等特殊情况的人群中也是如此。
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