Kidney Paired Donation (KPD) in Brazil: first 3-way case report.

IF 1.6 Q3 UROLOGY & NEPHROLOGY

Jornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia Pub Date : 2026-01-01 DOI:10.1590/2175-8239-JBN-2025-0177en

Juliana Bastos, Glaucio Silva de Souza, Marcio Luiz de Sousa, Pedro Bastos Guimarães de Almeida, Thais Freesz, David Jose de Barros Machado, Elias David-Neto, Gustavo Fernandes Ferreira

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Abstract

Kidney Paired Donation (KPD) is a transformative strategy in living kidney donor transplantation (LDKT), particularly for overcoming immunological barriers that preclude direct donation. In 2021, KPD accounted for one-fifth of adult LDKT and for half of LDKT for sensitized recipients in the United States. In Brazil, with a high prevalence of chronic kidney disease (CKD) and over 30,000 patients on transplant waiting lists, the demand for compatible donors far exceeds supply. This article presents a case report of KPD in the Brazilian context, illustrating its feasibility and highlighting challenges and considerations for broader implementation. The case demonstrates KPD's potential to increase transplant rates, improve outcomes, and reduce dialysis costs. Nevertheless, structural, ethical, and regulatory challenges remain. This report emphasizes the implications of expanding KPD as a sustainable, life-saving strategy in Brazil.

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巴西肾脏配对捐献（KPD）：首个3-way病例报告。

肾脏配对捐赠（KPD）是活体肾脏移植（LDKT）的一种变革性策略，特别是克服了排除直接捐赠的免疫障碍。2021年，在美国，KPD占成人LDKT的五分之一，占致敏受体LDKT的一半。在巴西，慢性肾脏疾病（CKD）的患病率很高，移植等候名单上有超过3万名患者，对兼容供体的需求远远超过供应。本文介绍了巴西背景下的KPD案例报告，说明了其可行性，并强调了更广泛实施的挑战和考虑因素。该病例证明了KPD在提高移植率、改善预后和降低透析成本方面的潜力。然而，结构、道德和监管方面的挑战依然存在。本报告强调了在巴西扩大KPD作为一项可持续的拯救生命战略的意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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