Infectious retinitis associated with JAK inhibitors: the ongoing duality of JAK inhibitors.

IF 3.8 Q2 OPHTHALMOLOGY

International Journal of Retina and Vitreous Pub Date : 2026-03-06 DOI:10.1186/s40942-026-00823-4

Jose S Pulido, Fukutaro Mano, Marcello Casella, Susumu Ishida

引用次数: 0

Abstract

PURPOSE: To discuss the recent evidence that Janus kinase (JAK) inhibitors can cause viral retinitis. METHODS: A commentary on the case report in this issue and a review of cases in the literature. RESULTS: A total of 6 cases have now been reported of cytomegalovirus retinitis associated with Jak inhibitors. Additionally, there was a case of bilateral toxoplasma retinitis and a case of herpetic scleritis. DISCUSSION: It is important to be aware of the potential blinding complications associated with JAK inhibitors and if the patient complains of acute vision loss and/or floaters, the patient should be emergently referred to a retina specialist.

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与JAK抑制剂相关的感染性视网膜炎：JAK抑制剂的持续双重性。

目的：探讨Janus激酶（JAK）抑制剂可引起病毒性视网膜炎的最新证据。方法：对本刊的病例报告进行评论，并对文献中的病例进行回顾。结果：目前共报道了6例与Jak抑制剂相关的巨细胞病毒视网膜炎。此外，还有1例双侧弓形虫视网膜炎和1例疱疹性巩膜炎。讨论：重要的是要意识到与JAK抑制剂相关的潜在致盲并发症，如果患者抱怨急性视力丧失和/或飞蚊症，患者应紧急转介给视网膜专家。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Retina and Vitreous Medicine-Ophthalmology

CiteScore

3.50

自引率

4.30%

发文量

审稿时长

19 weeks

期刊介绍： International Journal of Retina and Vitreous focuses on the ophthalmic subspecialty of vitreoretinal disorders. The journal presents original articles on new approaches to diagnosis, outcomes of clinical trials, innovations in pharmacological therapy and surgical techniques, as well as basic science advances that impact clinical practice. Topical areas include, but are not limited to: -Imaging of the retina, choroid and vitreous -Innovations in optical coherence tomography (OCT) -Small-gauge vitrectomy, retinal detachment, chromovitrectomy -Electroretinography (ERG), microperimetry, other functional tests -Intraocular tumors -Retinal pharmacotherapy & drug delivery -Diabetic retinopathy & other vascular diseases -Age-related macular degeneration (AMD) & other macular entities