The prognostic value of serum albumin in cystectomy: a systematic review and meta-analysis.

IF 4.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2026-03-06 DOI:10.1186/s40001-026-04167-5

Rui-Ping Su, Yi-Xuan Liu, Li-Li Peng, Fan He, Liang Liu

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引用次数: 0

Abstract

Objective: To explore the risk stratification and perioperative optimization path of albumin in perioperative period, such as giving priority to eras + nutritional support for high-risk (low albumin) patients, giving priority to urinary diversion with lower risk of complications, and strengthening postoperative monitoring and rehabilitation resource allocation.

Methods: The Cochrane Library, Embase, PubMed, Web of Science, Chinese National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodicals Database (VIP), Chinese Biomedical Literature Service System (SinoMed), and Wanfang databases were systematically searched from the inception to 20 June 2024. We conducted this meta-analysis about the prognostic indices of survival based on hazard ratio (HR), P-value or 95% confidence interval (95%CI) obtained from univariate or multivariate Cox regression analyses. Subgroup analysis, and sensitivity analysis were also conducted. Descriptive analyses were conducted when indicators could not be used for meta-analysis.

Results: Five articles, including 2,631 patients undergoing cystectomy, met the inclusion criteria. The fixed effect model showed that lower serum albumin was significantly associated with worse overall survival (OS) (HR: 1.73, 95% CI 1.42-2.11, p < 0.001) and cancer-specific survival (CSS)/recurrence-free survival (RFS) (HR: 1.66, 95% CI 1.19-2.30, p = 0.003). Furthermore, subgroup analysis based on the country of study and sample size indicated that our findings were reliable.

Conclusions: Our meta-analysis revealed that lower serum albumin level is associated with worse prognosis in patients undergoing cystectomy and may serve as an adjunctive marker within comprehensive prognostic models in patients with cystectomy.

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血清白蛋白在膀胱切除术中的预后价值：一项系统回顾和荟萃分析。

目的：探讨围手术期白蛋白的风险分层及围手术期优化路径，如对高危（低白蛋白）患者优先采用eras +营养支持，优先采用并发症风险较低的尿改道，加强术后监测及康复资源配置。方法：系统检索Cochrane Library、Embase、PubMed、Web of Science、中国知网（CNKI）、中国科技期刊数据库（VIP）、中国生物医学文献服务系统（SinoMed）和万方数据库，检索时间为建库至2024年6月20日。我们基于单因素或多因素Cox回归分析得出的风险比（HR）、p值或95%置信区间（95% ci）对生存预后指标进行了meta分析。并进行亚组分析和敏感性分析。当指标不能用于meta分析时，进行描述性分析。结果：5篇文章，包括2631例膀胱切除术患者，符合纳入标准。固定效应模型显示，较低的血清白蛋白水平与较差的总生存期（OS）显著相关（HR: 1.73, 95% CI 1.42-2.11, p）。结论：我们的荟萃分析显示，较低的血清白蛋白水平与膀胱切除术患者较差的预后相关，可以作为膀胱切除术患者综合预后模型的辅助指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.