Multifunctional carrier based on biocompatible artificial anionic polysaccharide, cross-linked with 90Y(III) ions and with a built-in antitumor agent

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2026-06-01 Epub Date: 2026-02-24 DOI:10.1016/j.apradiso.2026.112526

M.A. Orlova, V.V. Spiridonov, A.V. Gopin, T.P. Trofimova, M.Z. Bezhanidze, A.A. Yaroslavov, S.N. Kalmykov

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引用次数: 0

Abstract

For ⁹⁰Y obtained on a⁹⁰Sr/⁹⁰Y generator, a microgel based on carboxymethyl cellulose (CMC) is proposed as a multifunctional carrier platform for the radionuclide and the antitumor agent. Both binary (CMC-⁹⁰Y[Y] and CMC-⁹⁰Y) and ternary (⁹⁰Y[Y]-CMC-NO-synthase effector) microgels with different yttrium contents were synthesized and characterized. Both direct synthesis and isotope exchange used for the introduction of the radionuclide. In both cases, the degree of introduction was maximal. It was found that the size of the microgels and their cytotoxicity depend on the yttrium content, especially in the case of ternary (i.e. containing an organic component) microgels. This dependence is a result of changes in the structure of the formed particles and is confirmed by the data obtained by light scattering (D_h) and electrophoretic mobility (EPM) methods. The composition of the ternary microgels confirmed by IR spectroscopy.

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基于生物相容性人工阴离子多糖的多功能载体，与90Y（III）离子交联，并具有内置抗肿瘤剂。

对于在90sr /90Y发生器上获得的90Y，提出了一种基于羧甲基纤维素（CMC）的微凝胶作为放射性核素和抗肿瘤剂的多功能载体平台。合成了不同钇含量的二元微凝胶（CMC-90Y[Y]和CMC-90Y）和三元微凝胶（90Y[Y]- cmc - no合酶效效物），并对其进行了表征。直接合成和同位素交换都用于引入放射性核素。在这两种情况下，引入的程度都是最大的。研究发现，微凝胶的大小及其细胞毒性取决于钇的含量，特别是三元微凝胶（即含有有机成分）。这种依赖性是形成的颗粒结构变化的结果，并由光散射（Dh）和电泳迁移率（EPM）方法获得的数据证实。用红外光谱法确定了三元微凝胶的组成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.