Changes of Helicobacter pylori Infection Status and Risk of Precancerous Lesions: A Prospective Cohort Study in Chinese Population

IF 4.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Helicobacter Pub Date : 2026-03-05 DOI:10.1111/hel.70114

Xufei Xing, Renjia Zhao, Zixuan Cui, Qiaoyi Xu, Ziyu Yuan, Kelin Xu, Tiejun Zhang, Zhenqiu Liu, Yanfeng Jiang, Ming Lu, Weimin Ye, Chen Suo, Xingdong Chen

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引用次数: 0

Abstract

Objective

To evaluate the associations of both baseline serological profiles and serological transitions of Helicobacter pylori infection patterns with the risk of precancerous gastric lesions (PGLs).

Design

We analyzed data from 6208 participants in the FuSion cohort who underwent gastroscopy examination, with available H. pylori antibody and pepsinogen measurements at both baseline and follow-up. H. pylori status defined by IgG antibodies (Ab) and pepsinogens (PG), classified participants into four ABC groups. Multivariable logistic regression evaluated associations with PGLs across baseline and transition statuses. Trend tests were performed across the ABC groups and infection transition categories.

Results

A significant increasing trend in the PGLs prevalence and severity was observed across the ABC groups (p for trend < 0.05). Analysis of infection transitions revealed graded risk increases for PGLs from consistently negative to remained positive groups. Interestingly, even participants who seroreverted remained at significantly elevated risks of atrophic gastritis (adjusted odds ratio [aOR] = 2.01, 95% CI: 1.67–2.43) and intestinal metaplasia (aOR = 1.72, 95% CI: 1.14–2.51) compared to the persistently negative participants. The sensitivity analyses excluding baseline PG-positive subjects yielded similar results.

Conclusion

Long-term exposure to H. pylori is associated with an increased risk of PGLs, and this risk may remain elevated even after seroreversion.

查看原文本刊更多论文

幽门螺杆菌感染状况及癌前病变风险的变化：中国人群的前瞻性队列研究。

目的：评估幽门螺杆菌感染模式的基线血清学特征和血清学转变与胃癌前病变（PGLs）风险的关系。设计：我们分析了FuSion队列中6208名参与者的数据，他们接受了胃镜检查，并在基线和随访期间测量了幽门螺杆菌抗体和胃蛋白酶原。通过IgG抗体（Ab）和胃蛋白酶原（PG）来确定幽门螺杆菌的状态，将参与者分为四个ABC组。多变量逻辑回归评估了基线和过渡状态与pgl的关系。在ABC组和感染过渡类别之间进行趋势测试。结果：在ABC组中观察到pgl的患病率和严重程度有显著增加的趋势（p为趋势）。结论：长期暴露于幽门螺杆菌与pgl的风险增加有关，即使在血清逆转后这种风险仍可能升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Helicobacter 医学-微生物学

CiteScore

8.40

自引率

9.10%

发文量

审稿时长

2 months

期刊介绍： Helicobacter is edited by Professor David Y Graham. The editorial and peer review process is an independent process. Whenever there is a conflict of interest, the editor and editorial board will declare their interests and affiliations. Helicobacter recognises the critical role that has been established for Helicobacter pylori in peptic ulcer, gastric adenocarcinoma, and primary gastric lymphoma. As new helicobacter species are now regularly being discovered, Helicobacter covers the entire range of helicobacter research, increasing communication among the fields of gastroenterology; microbiology; vaccine development; laboratory animal science.