[Association of hematological coefficients of inflammation using high-density lipoproteins in evaluating the severity of mood disorders].

Abstract

Objective: Exploratory analysis of associations of indicators of systemic inflammation and lipid metabolism in males and females with mood disorders.

Material and methods: This retrospective study included 177 patients aged 18-60 years diagnosed with depressive episode/recurrent depressive disorder (DE/RDE) and bipolar affective disorder (BAD), of which 61.6% (n=109) were female. Patients were selected based on a review of medical records. From the medical records, data on age, gender, anthropometric indicators, and the results of the blood count (platelets, lymphocytes, neutrophils, monocytes) and blood chemistry (high-density lipoproteins - HDL) tests were collected, as well as the quantitative values of the Montgomery-Asberg Depression Rating Scale (MADRS) and the Young Mania Rating Scale (YMRS). Statistical analysis was performed in RStudio v2025.05.0+496.

Results: The results of the correlation analysis showed a significant relationship (p<0.05) between gender and hematological inflammation coefficients (HIC), as well as between gender and the severity of affective symptoms. In females with DE/RDE, the severity of depression was moderately and negatively correlated with the ratio of monocytes to HDL, and a weak but statistically significant positive correlation was found in BAD patients. In addition, women with DE/RDE had significant moderate negative correlations between the severity of depression and the platelet to HDL ratio. In contrast, males with DE/RDE had a significant moderate positive correlation between the severity of depression and the lymphocyte to HDL ratio. There were no associations between the severity of mania and any HICs in patients of either gender.

Conclusion: Significant associations were found between indicators of inflammation and lipid metabolism, and affective disorders, with the strongest correlations observed in females.