Bladder Exstrophy in a Female Fetus: Ultrasound and Autopsy Findings.

IF 0.8 4区医学 Q4 PATHOLOGY

Fetal and Pediatric Pathology Pub Date : 2026-03-01 Epub Date: 2026-03-04 DOI:10.1080/15513815.2026.2628770

Maria Paola Bonasoni, Giuseppina Comitini, Andrea Musarò, Flavio Vanacore, Immacolata Blasi, Giovanna Botticelli, Veronica Barbieri, Maria Marinelli, Francesca Peluso, Livia Garavelli, Khush Shah, Lorenzo Aguzzoli, Mariangela Pati

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引用次数: 0

Abstract

Introduction: Bladder exstrophy (BE) is a congenital anomaly within the exstrophy-epispadias complex (EEC), characterized by a defect in the closure of the lower abdominal wall and bladder. Case report: A female fetus at 20 weeks + 2 days showed at ultrasound (US) a homogeneous echogenic mass with a lobulated surface, protruding from the anterior lower abdominal wall. The bladder was not visualized. Doppler US displayed umbilical arteries laterally to the mass. The kidneys appeared normal. Amniotic fluid was regular. Legal termination of pregnancy occurred at 21 weeks + 4 days. Autopsy grossly and histologically confirmed BE. Microscopically, BE was layered by an urothelial-like epithelial layer and underneath, the muscularis propria was disarrayed with scarce nerve fibers, evidenced by immunohistochemistry for S-100. Conclusion: In case of prenatal diagnosis of BE, multidisciplinary counseling is mandatory for appropriate clinical management.

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女性胎儿膀胱外翻：超声和尸检结果。

简介：膀胱外翻（BE）是外翻-上膈复合体（EEC）内的一种先天性异常，其特征是下腹壁和膀胱的闭合缺陷。病例报告：一个20周+ 2天的女胎儿在超声检查（US）显示一个均匀的回声肿块，表面呈分叶状，从前下腹壁突出。膀胱未见。多普勒超声显示肿块外侧的脐动脉。肾脏显示正常。羊水正常。法定终止妊娠发生在21周+ 4天。尸检大体和组织学证实为BE。显微镜下，BE呈尿路上皮样上皮层状，S-100免疫组化证实其固有肌层紊乱，神经纤维稀少。结论：在产前诊断为BE的情况下，多学科咨询对临床管理是必要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Fetal and Pediatric Pathology 医学-病理学

CiteScore

3.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Fetal and Pediatric Pathology is an established bimonthly international journal that publishes data on diseases of the developing embryo, newborns, children, and adolescents. The journal publishes original and review articles and reportable case reports. The expanded scope of the journal encompasses molecular basis of genetic disorders; molecular basis of diseases that lead to implantation failures; molecular basis of abnormal placentation; placentology and molecular basis of habitual abortion; intrauterine development and molecular basis of embryonic death; pathogenisis and etiologic factors involved in sudden infant death syndrome; the underlying molecular basis, and pathogenesis of diseases that lead to morbidity and mortality in newborns; prenatal, perinatal, and pediatric diseases and molecular basis of diseases of childhood including solid tumors and tumors of the hematopoietic system; and experimental and molecular pathology.