Recent advances in the heart and soul of primary cardiac involvement and cardiovascular disease in systemic sclerosis

IF 7 2区医学 Q1 RHEUMATOLOGY

Best Practice & Research in Clinical Rheumatology Pub Date : 2026-05-01 Epub Date: 2026-03-04 DOI:10.1016/j.berh.2026.102124

Laura Ross , Cosimo Bruni

引用次数: 0

Abstract

Systemic sclerosis (SSc) has direct effects on the heart. Primary SSc-associated heart involvement (pSHI) is a spectrum of disease, with myriad presentations that range from acute heart failure and myocarditis, breathlessness due to diastolic dysfunction to asymptomatic ventricular ectopy. There have been recent significant advances towards the standardized identification of pSHI with the development of both a consensus definition and classification criteria for pSHI. Such instruments are required to improve the quality of research in this area by enabling the recruitment of homogenous patient populations and permitting comparison of results between studies. Prospective studies are required to test the efficacy of screening strategies to identify pSHI at an early stage, as well as the effectiveness of immunosuppressive, anti-fibrotic and heart failure management strategies to reverse the disease related effects of SSc on the heart.

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系统性硬化症中原发性心脏受累和心血管疾病的心脏和灵魂研究进展。

系统性硬化（SSc）对心脏有直接影响。原发性ssc相关性心脏受累（pSHI）是一种谱系疾病，有多种表现，从急性心力衰竭和心肌炎、舒张功能障碍引起的呼吸困难到无症状心室异位。最近，随着对非公有制经济的共识定义和分类标准的制定，在非公有制经济的标准化鉴定方面取得了重大进展。需要这样的工具来提高这一领域的研究质量，使其能够招募相同的患者群体，并允许比较研究之间的结果。需要前瞻性研究来测试筛查策略在早期识别pSHI的有效性，以及免疫抑制、抗纤维化和心力衰竭管理策略在逆转SSc对心脏的疾病相关影响方面的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research in Clinical Rheumatology 医学-风湿病学

CiteScore

9.40

自引率

0.00%

发文量

审稿时长

27 days

期刊介绍： Evidence-based updates of best clinical practice across the spectrum of musculoskeletal conditions. Best Practice & Research: Clinical Rheumatology keeps the clinician or trainee informed of the latest developments and current recommended practice in the rapidly advancing fields of musculoskeletal conditions and science. The series provides a continuous update of current clinical practice. It is a topical serial publication that covers the spectrum of musculoskeletal conditions in a 4-year cycle. Each topic-based issue contains around 200 pages of practical, evidence-based review articles, which integrate the results from the latest original research with current clinical practice and thinking to provide a continuous update. Each issue follows a problem-orientated approach that focuses on the key questions to be addressed, clearly defining what is known and not known. The review articles seek to address the clinical issues of diagnosis, treatment and patient management. Management is described in practical terms so that it can be applied to the individual patient. The serial is aimed at the physician in both practice and training.