Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections

IF 8.4 1区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS

JACC: Basic to Translational Science Pub Date : 2026-04-01 Epub Date: 2026-03-03 DOI:10.1016/j.jacbts.2026.101511

Yuping Zou MS , Siyu Wei PhD , Qinduo Ren MS, Tianyu Zhou MS, Songlin Lu MS, Ruilin Li MS, Yingnan Ma PhD, Linna Yuan MS, Jiacheng Wang MS, Wei She MS, Xuying Guo PhD, Junxian Tao PhD, Shuo Bi MS, Hongsheng Tian MS, Chen Sun PhD, Haiyan Chen PhD, Jing Xu PhD, Yu Dong MS, Jingxuan Kang PhD, Hongchao Lv PhD, Mingming Zhang PhD

{"title":"Global Burden of Rheumatic Heart Disease (1990-2021), Attributable Risk Factors, and Future Projections","authors":"Yuping Zou MS , Siyu Wei PhD , Qinduo Ren MS, Tianyu Zhou MS, Songlin Lu MS, Ruilin Li MS, Yingnan Ma PhD, Linna Yuan MS, Jiacheng Wang MS, Wei She MS, Xuying Guo PhD, Junxian Tao PhD, Shuo Bi MS, Hongsheng Tian MS, Chen Sun PhD, Haiyan Chen PhD, Jing Xu PhD, Yu Dong MS, Jingxuan Kang PhD, Hongchao Lv PhD, Mingming Zhang PhD","doi":"10.1016/j.jacbts.2026.101511","DOIUrl":null,"url":null,"abstract":"<div><div>Rheumatic heart disease (RHD) is a chronic valvular disorder caused by acute rheumatic fever. It mostly affects the mitral valve and leads to thickening. The present study employs the GBD (Global Burden of Diseases, Injuries, and Risk Factors Study 2021) to analyze the global burden of RHD. The study investigates trends in incidence, prevalence, disability-adjusted life-years, and mortality from 1990 to 2021 across regions and 204 countries and territories, exploring difference with sex, age, and sociodemographic index. Two-sample Mendelian randomization identified high systolic blood pressure and high body mass index as causal risk factors for RHD. Although there was a slight increase in age-standardized prevalence and incidence rates, there was a decline in mortality and disability-adjusted life-year rates. Projections indicate a persistent upward trend in the incidence of the condition from 2022 to 2050. The findings emphasize the persistent global burden of RHD and underscore the necessity for targeted interventions.</div></div>","PeriodicalId":14831,"journal":{"name":"JACC: Basic to Translational Science","volume":"11 4","pages":"Article 101511"},"PeriodicalIF":8.4000,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JACC: Basic to Translational Science","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452302X2600029X","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/3/3 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

Abstract

Rheumatic heart disease (RHD) is a chronic valvular disorder caused by acute rheumatic fever. It mostly affects the mitral valve and leads to thickening. The present study employs the GBD (Global Burden of Diseases, Injuries, and Risk Factors Study 2021) to analyze the global burden of RHD. The study investigates trends in incidence, prevalence, disability-adjusted life-years, and mortality from 1990 to 2021 across regions and 204 countries and territories, exploring difference with sex, age, and sociodemographic index. Two-sample Mendelian randomization identified high systolic blood pressure and high body mass index as causal risk factors for RHD. Although there was a slight increase in age-standardized prevalence and incidence rates, there was a decline in mortality and disability-adjusted life-year rates. Projections indicate a persistent upward trend in the incidence of the condition from 2022 to 2050. The findings emphasize the persistent global burden of RHD and underscore the necessity for targeted interventions.

查看原文本刊更多论文

全球风湿性心脏病负担（1990-2021）、归因风险因素和未来预测

风湿性心脏病（RHD）是一种由急性风湿热引起的慢性瓣膜疾病。它主要影响二尖瓣并导致其增厚。本研究采用GBD（2021年全球疾病、损伤和风险因素负担研究）来分析RHD的全球负担。该研究调查了1990年至2021年各地区和204个国家和地区的发病率、患病率、残疾调整生命年和死亡率的趋势，探讨了性别、年龄和社会人口指数的差异。双样本孟德尔随机化确定了高收缩压和高体重指数是RHD的因果危险因素。虽然年龄标准化流行率和发病率略有增加，但死亡率和残疾调整生命年率有所下降。预测表明，从2022年到2050年，该病的发病率呈持续上升趋势。研究结果强调了RHD持续的全球负担，并强调了有针对性干预的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

JACC: Basic to Translational Science CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

14.20

自引率

1.00%

发文量

161

审稿时长

16 weeks

期刊介绍： JACC: Basic to Translational Science is an open access journal that is part of the renowned Journal of the American College of Cardiology (JACC). It focuses on advancing the field of Translational Cardiovascular Medicine and aims to accelerate the translation of new scientific discoveries into therapies that improve outcomes for patients with or at risk for Cardiovascular Disease. The journal covers thematic areas such as pre-clinical research, clinical trials, personalized medicine, novel drugs, devices, and biologics, proteomics, genomics, and metabolomics, as well as early phase clinical trial methodology.