Liquid crystal-based biosensors for clinical diagnostics

IF 2.9 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY

Clinica Chimica Acta Pub Date : 2026-05-15 Epub Date: 2026-03-02 DOI:10.1016/j.cca.2026.120926

Qamar Abuhassan , Jamal I. Al-Nabulsi , Subbulakshmi Ganesan , Subhashree Ray , V. Ramesh Kumar , Vipasha Sharma , Ashish Singh Chauhan , Zafar Aminov

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Abstract

Liquid crystal (LC)-based biosensors are emerging as a powerful and versatile platform for the detection of a wide range of biomarkers. This review comprehensively examines the fundamental principles underpinning these sensors, where the precise orientation of LCs is perturbed by biological binding events, translating molecular interactions into macroscopic optical signals visible under polarized light. This review article provides an overview of LC-based diagnostic technologies. We begin by introducing the fundamental materials science of LCs and the core optical detection methods that underpin their sensing capabilities. Subsequently, we critically examine their emerging applications in clinical diagnostics, with a focused analysis of their use in detecting major diseases such as cancer, diabetes, neurological disorders, and various infectious agents. We discuss recent advancements in the design of LC biosensors for detecting proteins, nucleic acids, and small molecules, highlighting their exceptional sensitivity and label-free operation. Finally, we offer a perspective on the future development and commercialization potential of LC biosensors in the evolving diagnostic landscape.

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用于临床诊断的液晶生物传感器。

基于液晶（LC）的生物传感器正在成为一种功能强大、用途广泛的检测各种生物标志物的平台。这篇综述全面研究了支撑这些传感器的基本原理，其中lc的精确定向受到生物结合事件的干扰，将分子相互作用转化为在偏振光下可见的宏观光信号。本文综述了基于lc的诊断技术。我们首先介绍LCs的基础材料科学和支撑其传感能力的核心光学检测方法。随后，我们批判性地研究了它们在临床诊断中的新兴应用，重点分析了它们在检测癌症、糖尿病、神经系统疾病和各种传染性病原体等重大疾病中的应用。我们讨论了用于检测蛋白质、核酸和小分子的LC生物传感器设计的最新进展，强调了它们卓越的灵敏度和无标签操作。最后，我们对LC生物传感器在不断发展的诊断领域的未来发展和商业化潜力进行了展望。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Chimica Acta 医学-医学实验技术

CiteScore

10.10

自引率

2.00%

发文量

1268

审稿时长

23 days

期刊介绍： The Official Journal of the International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Clinica Chimica Acta is a high-quality journal which publishes original Research Communications in the field of clinical chemistry and laboratory medicine, defined as the diagnostic application of chemistry, biochemistry, immunochemistry, biochemical aspects of hematology, toxicology, and molecular biology to the study of human disease in body fluids and cells. The objective of the journal is to publish novel information leading to a better understanding of biological mechanisms of human diseases, their prevention, diagnosis, and patient management. Reports of an applied clinical character are also welcome. Papers concerned with normal metabolic processes or with constituents of normal cells or body fluids, such as reports of experimental or clinical studies in animals, are only considered when they are clearly and directly relevant to human disease. Evaluation of commercial products have a low priority for publication, unless they are novel or represent a technological breakthrough. Studies dealing with effects of drugs and natural products and studies dealing with the redox status in various diseases are not within the journal''s scope. Development and evaluation of novel analytical methodologies where applicable to diagnostic clinical chemistry and laboratory medicine, including point-of-care testing, and topics on laboratory management and informatics will also be considered. Studies focused on emerging diagnostic technologies and (big) data analysis procedures including digitalization, mobile Health, and artificial Intelligence applied to Laboratory Medicine are also of interest.