Mohammad Atik, Mohd Shahid, Iram Naaz, Sabiha Fatima, Mohd Aleemuddin Quamri, K Radhika
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引用次数: 0
Abstract
Background: Type 2 diabetes mellitus (T2DM) is among the most rapidly escalating global health crises of the 21st century. Conventional pharmacological management has unnecessary side effects. Therefore, exploring a safe and effective drug to manage T2DM is a foremost priority.
Primary study objectives: To evaluate the impact of Survali (Celosia argentea Linn.) seeds as an adjuvant medication in T2DM.
Methods: Forty participants with T2DM were randomly assigned to test (n=20) and control (n=20) groups in a randomized, double-blind, placebo-controlled trial.
Intervention: For 8 weeks, the test group received Celosia argentea Linn. seed powder, and the control group received roasted wheat flour; both were administered 4 g/day in two equal divided doses with water as a complement to conventional medicine.
Primary outcome measures: HbA1c was assessed at baseline and at the end of the treatment.
Secondary outcome measures: These include changes in fasting and postprandial blood sugar, and the Asian Diabetes Quality of Life Questionnaire (ADQOL). Subjective parameters (polyphagia, polydipsia, polyuria, and tiredness) were assessed by an arbitrary scale fortnightly.
Setting: This clinical trial was conducted at the National Institute of Unani Medicine, Bengaluru, India.
Results: All 40 participants completed the study. The test drug showed a statistically significant difference in HbA1c and ADQOL (P < .001). However, the control group demonstrated no significant impact on any of the measures. A significant reduction in fasting blood sugar was observed in the test group, compared to baseline (P = .01), while no such significant changes were observed in the control group. The subjective parameters were non-significant, as both groups showed similar reduction in symptoms (P > .05). There was no significant difference between the groups in terms of safety parameters.
Conclusion: Celosia argentea Linn. seeds demonstrate efficacy as an adjuvant in the management of T2DM; further research is warranted to confirm the long-term efficacy and safety.
Keywords: Fasting Blood Sugar, Unani Medicine, Postprandial Blood Sugar, HbA1c, Asian Diabetes Quality of Life Questionnaire.
期刊介绍：
Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field.
Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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