Mechanical behaviors of an asymmetric transcatheter prosthetic valve in bicuspid aortic valve

IF 3 3区医学 Q2 BIOPHYSICS

Biomechanics and Modeling in Mechanobiology Pub Date : 2026-03-05 DOI:10.1007/s10237-026-02048-8

Xiang Shen, Huilin Yao, Zewen He, Yue Xu, Jiahao Chen, Jianwei Gao, Yizhe Wang, Qiang Liu, Yuan Wang, Hongyu Liang

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Abstract

When a Transcatheter heart valve (THV) is implanted in a bicuspid aortic valve (BAV), the interventional valve may experience elliptical deformation, thereby reducing its durability. In this study, a novel Asymmetric Artificial Interventional Valve (AAIV) was designed. The deployment of the AAIV in the BAV was simulated and compared to that of a THV. The synergistic effects of the AAIV (0.1, 0.2, and 0.3) eccentricity and annulus eccentricity (0.1, 0.2, and 0.3) on the deployment of the interventional valve were studied. Besides, the influence of native leaflet calcification on the deployment of the AAIV was also studied. The results demonstrated the maximum stress of the AAIV (0.590 MPa) is 8.2% lower than that of the THV (0.643 MPa). When the AAIV eccentricity is equal to the annulus eccentricity, the stress of the prosthetic valve is the highest, representing the most unfavorable condition for the long-term durability of the prosthetic valve. Calcification of the native leaflet can increase the stress of the prosthetic valve. In addition, with the increase of annulus eccentricity, the stress of the prosthetic valve tends to increase. This study might provide insights for the design of personalized high-performance interventional valves and their rational selection in clinical practice.

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非对称经导管人工瓣膜在二尖瓣主动脉瓣中的力学行为。

当经导管心脏瓣膜（THV）植入双尖瓣主动脉瓣膜（BAV）时，介入瓣膜可能发生椭圆变形，从而降低其耐久性。本文设计了一种新型的非对称人工介入瓣膜（AAIV）。模拟了AAIV在BAV中的部署，并与THV的部署进行了比较。研究了AAIV（0.1、0.2、0.3）偏心率和环空偏心率（0.1、0.2、0.3）对介入瓣膜部署的协同效应。此外，还研究了原生小叶钙化对AAIV展开的影响。结果表明：AAIV的最大应力（0.590 MPa）比THV的最大应力（0.643 MPa）低8.2%；当AAIV偏心距等于环空偏心距时，人工瓣膜的应力最大，这对人工瓣膜的长期耐用性是最不利的。原生小叶的钙化会增加人工瓣膜的应力。此外，随着环空偏心率的增大，假体瓣膜的应力有增大的趋势。本研究可为个性化高性能介入瓣膜的设计及临床合理选择提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomechanics and Modeling in Mechanobiology 工程技术-工程：生物医学

CiteScore

7.10

自引率

8.60%

发文量

119

审稿时长

6 months

期刊介绍： Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that (1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury, (2) identify and quantify mechanosensitive responses and their mechanisms, (3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and (4) report discoveries that advance therapeutic and diagnostic procedures. Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.