Bacteria outer membrane-based oxygen gels alleviate tumor hypoxia for enhanced systemic immune response to radiotherapy

IF 7.4 2区材料科学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

Science China Materials Pub Date : 2026-01-07 DOI:10.1007/s40843-025-3581-2

Deyuan Zheng (, ), Junhong Yao (, ), Haiheng Xu (, ), Shuqin Xiong (, ), Qingsong Ye (, ), Yiyun Chen (, ), Chuan Zhao (, ), Min Zhang (, ), Xuehui Rui (, ), Jinhui Wu (, )

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引用次数: 0

Abstract

Radiotherapy (RT) is considered a standard cancer treatment that directly kills tumor cells and promotes a systemic immune response. However, RT may also lead to tumor hypoxia, which further inhibits the antigen-presenting function of dendritic cells (DCs) and thereby weakens the systemic anti-tumor immune response induced by radiotherapy. In this study, the oxygen-loaded in situ gels carrying bacterial outer membrane (MOGel) were synthesized. As the gels slowly degraded, oxygen was gradually released to alleviate tumor hypoxia. The released bacterial outer membrane (OM) continuously activated DCs, enhancing their antigen-presenting capability. The results demonstrated that MOGel combined with RT induced the strongest tumor cell apoptosis in vitro and achieved a 80% tumor suppression rate in a colon cancer orthotopic model. Importantly, MOGel+RT induced an enhanced abscopal effect, and hypoxia and enhanced DCs activation contributed to the systemic immune response. Thus, OM-based oxygen gels may offer a novel strategy for enhancing the systemic immune response to RT.

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细菌外膜氧凝胶缓解肿瘤缺氧，增强全身放射免疫反应

放射治疗（RT）被认为是一种标准的癌症治疗方法，直接杀死肿瘤细胞并促进全身免疫反应。然而，RT也可能导致肿瘤缺氧，进一步抑制树突状细胞（dendritic cells, dc）的抗原呈递功能，从而削弱放疗诱导的全身抗肿瘤免疫反应。本研究合成了携带细菌外膜的载氧原位凝胶（MOGel）。随着凝胶的缓慢降解，氧气逐渐释放，缓解肿瘤缺氧。释放的细菌外膜（OM）不断激活树突状细胞，增强其抗原呈递能力。结果表明，MOGel联合RT在体外诱导肿瘤细胞凋亡最强，在结肠癌原位模型中达到80%的肿瘤抑制率。重要的是，MOGel+RT诱导体外效应增强，缺氧和DCs激活增强有助于全身免疫反应。因此，基于om的氧凝胶可能为增强对RT的全身免疫反应提供了一种新的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science China Materials Materials Science-General Materials Science

CiteScore

11.40

自引率

7.40%

发文量

949

期刊介绍： Science China Materials (SCM) is a globally peer-reviewed journal that covers all facets of materials science. It is supervised by the Chinese Academy of Sciences and co-sponsored by the Chinese Academy of Sciences and the National Natural Science Foundation of China. The journal is jointly published monthly in both printed and electronic forms by Science China Press and Springer. The aim of SCM is to encourage communication of high-quality, innovative research results at the cutting-edge interface of materials science with chemistry, physics, biology, and engineering. It focuses on breakthroughs from around the world and aims to become a world-leading academic journal for materials science.