{"title":"Integrated LC-OCT/Raman Microspectroscopy: A Novel Diagnostic Approach in Ophthalmology Demonstrated in a Case Study.","authors":"Ayadh Meriem, Dorado Cortez Christian, Ogien Jonas, Vanden-Bossche Arnaud, Camy Florian, Cinotti Elisa, Grivet Damien, Dubois Arnaud, Perrot Jean-Luc","doi":"10.1002/jbio.70245","DOIUrl":null,"url":null,"abstract":"<p><p>Integrated LC-OCT and Raman microspectroscopy enable the non-invasive identification of conjunctival hydroxyapatite calcifications, providing a dual morphological and molecular diagnostic approach. This bimodal technique successfully identifies microcrystals that are often undetectable by conventional histology due to their solubility and weak birefringence.</p>","PeriodicalId":94068,"journal":{"name":"Journal of biophotonics","volume":"19 3","pages":"e70245"},"PeriodicalIF":2.3000,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of biophotonics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/jbio.70245","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Integrated LC-OCT and Raman microspectroscopy enable the non-invasive identification of conjunctival hydroxyapatite calcifications, providing a dual morphological and molecular diagnostic approach. This bimodal technique successfully identifies microcrystals that are often undetectable by conventional histology due to their solubility and weak birefringence.
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