Posterior Atrophy is a Neuroimaging Marker of Mild Cognitive Impairment in Parkinson's Disease.

IF 1 4区医学 Q4 CLINICAL NEUROLOGY

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2026-02-02 eCollection Date: 2026-01-01 DOI:10.29399/npa.28821

Ulaş Ay, Zerrin Yıldırım, Ani Kicik, Emel Erdogdu, Başar Bilgiç, Hasmet Hanagasi, Esin Ozturk-Isık, Tamer Demiralp, Hakan Gurvit

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引用次数: 0

Abstract

Introduction: Although there are several studies on the neuroanatomical mechanisms underlying Parkinson's disease (PD)-associated cognitive impairment, the clinical usefulness of the findings from these investigations is limited. In this study, we aimed to identify magnetic resonance imaging (MRI) markers that can be practically utilized for diagnosing PD-associated cognitive impairment using a visual rating scale (VRS).

Methods: Anatomical MRIs of cognitively normal (PD-CN), and PD with mild cognitive impairment (PD-MCI) patients were visually evaluated for six bilateral cortical regions. Then, hypothesis-driven cortical thickness analysis (CTA) was performed in the regions obtained from VRS.

Results: As a consequence of VRS, a significant difference was found between the two groups with regards to right posterior atrophy (PA) scores (pFDR-corr = 0.042, Cohen's d= 1.06). Hypothesis-driven CTA confirmed the result of VRS by revealing cortical thinning at the precuneus and parieto-occipital sulcus junction (Max. T= 6.171, P= 0.0006, MNI_{x, y, z} = 11.0, -62.2, 25.4). The area under the curve was 0.75, showing a good association between the PD-MCI and the right PA score. The cut-off for maximum accuracy was ≥ 2, based on the highest sum of sensitivity (0.68) and specificity (0.72).

Conclusions: Our findings indicate that right PA atrophy may be helpful for clinicians in the diagnosis of PD-associated cognitive impairment.

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后叶萎缩是帕金森病轻度认知障碍的神经影像学标志。

虽然有一些关于帕金森病（PD）相关认知障碍的神经解剖学机制的研究，但这些研究结果的临床实用性是有限的。在这项研究中，我们旨在利用视觉评定量表（VRS）确定可用于诊断pd相关认知障碍的磁共振成像（MRI）标记物。方法：对认知正常（PD- cn）和PD合并轻度认知障碍（PD- mci）患者的6个双侧皮质区进行解剖mri视觉评价。然后，对VRS获得的区域进行假设驱动的皮质厚度分析（CTA）。结果：经VRS治疗后，两组右后侧萎缩（PA）评分差异有统计学意义（pFDR-corr = 0.042, Cohen’s d= 1.06）。假设驱动的CTA通过显示楔前叶和顶枕沟交界处的皮质变薄证实了VRS的结果。T = 6.171, P = 0.0006, MNIx, y, z = 11.0, -62.2, 25.4)。曲线下面积为0.75，表明PD-MCI与右侧PA评分有良好的相关性。基于灵敏度（0.68）和特异性（0.72）的最高总和，最高准确度的截止值≥2。结论：我们的研究结果表明，右侧PA萎缩可能有助于临床医生诊断pd相关认知障碍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.