NQO1 and NQO2 Gene Polymorphisms Related to Methamphetamine-Associated Psychosis in the Makassar Population, Indonesia.

IF 1 4区医学 Q4 CLINICAL NEUROLOGY

Noropsikiyatri Arsivi-Archives of Neuropsychiatry Pub Date : 2026-02-01 eCollection Date: 2026-01-01 DOI:10.29399/npa.29016

Dani Haryanto Ludong, Tri Supartını, Ismail Ismaıl

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引用次数: 0

Abstract

Introduction: This study investigates the relationship between NQO1 and NQO2 gene polymorphisms and methamphetamine-associated psychosis (MAP) in the Makassar population.

Methods: Case-Control Study to determine the role of the NQO1 and NQO2 genes in the onset of psychotic symptoms due to methamphetamine abuse. The control group consists of individuals who consume methamphetamine without psychotic characteristics (n=139), while the case group consists of individuals who consume methamphetamine with psychotic characteristics (n=128).

Results: The NQO1 gene polymorphism demonstrates a significant association with the duration of MAP, with the TT genotype and the T allele occurs more frequently in prolonged cases. The CT genotype is linked to an increased risk of spontaneous relapse, while the TT genotype is more prevalent among patients with polysubstance abuse. Additionally, the NQO2 (I/D) gene polymorphism indicates a trend towards differential genotype distribution in patients with MAP, with the DD genotype appearing more frequently in prolonged cases, and the I allele associated with a heightened risk of spontaneous relapse.

Conclusion: These findings suggest that polymorphisms in the NQO1 and NQO2 genes may play a role in the susceptibility to and clinical manifestations of MAP within the Makassar population.

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印尼望加锡人群与甲基苯丙胺相关精神病相关的NQO1和NQO2基因多态性

摘要：本研究探讨了望加锡人群NQO1和NQO2基因多态性与甲基苯甲胺相关精神病（methamphetamin -associated psychosis， MAP）的关系。方法：通过病例对照研究，确定NQO1和NQO2基因在甲基苯丙胺滥用后精神病症状发生中的作用。对照组由无精神病特征的甲基苯丙胺吸食者组成（n=139），而病例组由有精神病特征的甲基苯丙胺吸食者组成（n=128）。结果：NQO1基因多态性与MAP持续时间显著相关，TT基因型和T等位基因在MAP持续时间越长越常见。CT基因型与自发复发的风险增加有关，而TT基因型在多药物滥用患者中更为普遍。此外，NQO2 （I/D）基因多态性表明MAP患者有差异基因型分布的趋势，DD基因型在长期病例中更频繁出现，I等位基因与自发复发的风险增加有关。结论：NQO1和NQO2基因多态性可能与望加锡人群MAP易感性和临床表现有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Noropsikiyatri Arsivi-Archives of Neuropsychiatry CLINICAL NEUROLOGY-

CiteScore

1.70

自引率

9.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Archives of Neuropsychiatry (Arch Neuropsychiatry) is the official journal of the Turkish Neuropsychiatric Society. It is published quarterly, and four editions annually constitute a volume. Archives of Neuropsychiatry is a peer reviewed scientific journal that publishes articles on psychiatry, neurology, and behavioural sciences. Both clinical and basic science contributions are welcomed. Submissions that address topics in the interface of neurology and psychiatry are encouraged. The content covers original research articles, reviews, letters to the editor, and case reports.