Viral zoonosis and human cancer: further perspectives and considerations.

IF 3.2 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2026-03-03 DOI:10.1186/s13027-026-00745-8

Brian Salmons, Walter H Gunzburg

引用次数: 0

Abstract

A recent review by Aguayo appearing in Infectious Agents and Cancer gave a timely overview of viruses that have been associated with human breast cancer. In this Matters Arising article, we discuss some critical additional points and concerns that are pertinent for this important and contentious research focus, in particular as it pertains to the involvement of the retrovirus mouse mammary tumor virus and its closely related human betaretrovirus form. This includes additional evidence for zoonotic as well as horizontal transfer of the virus and also odds ratio data on the likelihood of an involvement of the viruses proposed to be involved in human breast cancer. In our opinion, this information redresses the balance of the Aguayo review article and make a much more compelling case for this retrovirus being one of the causes of human breast cancer.Clinical trial number Not applicable.

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病毒性人畜共患病与人类癌症：进一步的观点和考虑。

Aguayo最近发表在《感染因子与癌症》杂志上的一篇综述及时地概述了与人类乳腺癌相关的病毒。在这篇文章中，我们讨论了与这一重要而有争议的研究焦点相关的一些关键的附加点和关注点，特别是因为它涉及小鼠乳腺肿瘤病毒逆转录病毒及其密切相关的人类β -逆转录病毒形式。这包括关于人畜共患病和病毒水平传播的额外证据，以及关于被认为与人类乳腺癌有关的病毒参与的可能性的比值比数据。在我们看来，这一信息纠正了Aguayo评论文章的平衡，并为这种逆转录病毒是人类乳腺癌的原因之一提供了一个更有说服力的案例。临床试验编号不适用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.