Bone marrow adipose tissue in obesity: a previously underappreciated but promising therapeutic target.

IF 4.8 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

European Journal of Medical Research Pub Date : 2026-03-03 DOI:10.1186/s40001-026-04162-w

Hai Long Yu, Rui Chen, Suwen Sun, Ruixian Zhou

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Abstract

Bone marrow adipose tissue (BMAT) is an important modulator of metabolic and skeletal homeostasis in obesity. This review summarises current evidence supporting mechanistic links between BMAT and the development and progression of obesity. Accumulating data indicate that, beyond serving as a distinct adipose depot, BMAT functions as a dynamic and adaptive regulator within the bone marrow (BM) microenvironment under obese conditions. Therefore, limiting BM adipogenesis, regulating BMAT-derived adipokines, reversing metabolic dysfunction, and modulating systemic energy homeostasis have been proposed as potential therapeutic strategies for obesity. Collectively, BMAT is a previously underappreciated yet promising target for tailored, mechanism-based therapeutic strategies in obesity. Future research should prioritise mechanistic dissection and clinical validation of BMAT-targeted strategies, together with improved imaging and quantitative methodologies and Traditional Chinese Medicine (TCM)-informed system-level regulatory approaches, to facilitate their translation into effective therapies for obesity and related metabolic disorders.

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骨髓脂肪组织在肥胖：一个以前未被重视但有希望的治疗目标。

骨髓脂肪组织（BMAT）是肥胖代谢和骨骼稳态的重要调节因子。本综述总结了目前支持BMAT与肥胖发生和发展之间机制联系的证据。越来越多的数据表明，除了作为一个独特的脂肪储存库，在肥胖条件下，BMAT在骨髓（BM）微环境中还起着动态和适应性调节作用。因此，限制BM脂肪生成、调节BM来源的脂肪因子、逆转代谢功能障碍和调节全身能量稳态已被提出作为肥胖的潜在治疗策略。总的来说，BMAT是一个以前被低估但有希望的目标，可以为肥胖量身定制，基于机制的治疗策略。未来的研究应优先考虑bmat靶向策略的机制解剖和临床验证，以及改进的成像和定量方法以及中医知情的系统级调节方法，以促进其转化为肥胖和相关代谢紊乱的有效治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Medical Research 医学-医学：研究与实验

CiteScore

3.20

自引率

0.00%

发文量

247

审稿时长

>12 weeks

期刊介绍： European Journal of Medical Research publishes translational and clinical research of international interest across all medical disciplines, enabling clinicians and other researchers to learn about developments and innovations within these disciplines and across the boundaries between disciplines. The journal publishes high quality research and reviews and aims to ensure that the results of all well-conducted research are published, regardless of their outcome.