Melissa phospholipids improves sleep quality and mental well-being: concluding results from clinical study in adults with emotional distress.

IF 4.5 4区医学 Q2 FOOD SCIENCE & TECHNOLOGY

Food & Nutrition Research Pub Date : 2026-01-31 eCollection Date: 2026-01-01 DOI:10.29219/fnr.v70.13729

Mariangela Rondanelli, Giuseppe Mazzola, Gaetan Claude Barrile, Paola Misiano, Simone Perna

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引用次数: 0

Abstract

Background: Melissa officinalis L. (lemon balm) is a botanical support widely used for its calming and sleep-promoting properties.

Objective: To evaluate the impact of daily supplementation with Melissa phospholipids (MOP) at 200 or 400 mg for 3 weeks on sleep quality and psychological well-being in adults with emotional distress and poor sleep quality.

Design: This prospective, open-label, dose-comparison clinical study enrolled 32 adults with poor sleep quality and/or clinically significant emotional distress. Participants received daily supplementation with either 200 or 400 mg/day MOP for 3 weeks. Sleep quality (primary endpoint) was assessed using the Pittsburgh Sleep Quality Index (PSQI) at baseline (T0), and week 3 (T1). Secondary endpoints included depression, anxiety, and stress, positive and negative affect, mental well-being, and quality of life. Safety was also assessed through adherence monitoring, documentation of side effects or adverse events, and by routine blood biochemistry parameters of liver and renal functions.

Results: PSQI scores significantly improved over time (P < 0.0001), with greater and earlier benefits at 400 mg/day (-30% vs. -15%; P < 0.05). The 400 mg dose also produced significant reductions in depression (-26%), anxiety (-18%), and stress (-22%) scores (all P < 0.001), together with increased positive and negative affect together with Warwick-Edinburgh Mental Well-Being Scale (+15%). Quality of life improved across total score (33%) and its four domains, with significant results in physical well-being (P < 0.05). No statistically significant changes in safety parameters were detected and no adverse effects were reported.

Discussion: MOP, particularly at 400 mg/day, confirmed to significantly improve sleep and life quality, mood, and overall mental well-being.

Conclusion: These findings support and extend the health benefits of MOP as a well-tolerated, safe natural approach in a dose-dependent frame to managing sleep quality and emotional distress. Future placebo-controlled trials are warranted to confirm these results and further elucidate the underlying mechanisms of action.

查看原文本刊更多论文

Melissa磷脂改善睡眠质量和精神健康：成人情绪困扰的临床研究结论。

背景：柠檬香蜂草（Melissa officinalis L.）是一种植物支持物，因其镇静和促进睡眠的特性而被广泛使用。目的：评价每日补充200或400 mg Melissa磷脂（MOP） 3周对情绪困扰和睡眠质量差的成年人睡眠质量和心理健康的影响。设计：这项前瞻性、开放标签、剂量比较的临床研究招募了32名睡眠质量差和/或临床显著情绪困扰的成年人。参与者每天补充200或400毫克/天的MOP，持续3周。在基线（T0）和第3周（T1）使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量（主要终点）。次要终点包括抑郁、焦虑和压力、积极和消极影响、心理健康和生活质量。安全性还通过依从性监测、副作用或不良事件的记录以及肝肾功能的常规血液生化参数来评估。结果：PSQI评分随着时间的推移显著改善（P < 0.0001）， 400 mg/天的获益更大、更早（-30% vs -15%; P < 0.05）。400mg剂量还显著降低了抑郁（-26%）、焦虑（-18%）和压力（-22%）得分（均P < 0.001），并增加了积极和消极情绪，以及沃里克-爱丁堡心理健康量表（+15%）。生活质量在总分及其四个领域均有改善（33%），在身体健康方面有显著改善（P < 0.05）。安全参数未发现统计学上显著的变化，也未报告不良反应。讨论：MOP，特别是400毫克/天，证实可显着改善睡眠和生活质量，情绪和整体心理健康。结论：这些发现支持并扩展了MOP作为一种在剂量依赖框架下耐受良好、安全的天然方法来管理睡眠质量和情绪困扰的健康益处。未来的安慰剂对照试验有必要证实这些结果，并进一步阐明潜在的作用机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Food & Nutrition Research FOOD SCIENCE & TECHNOLOGY-NUTRITION & DIETETICS

CiteScore

5.20

自引率

9.10%

发文量

审稿时长

14 weeks

期刊介绍： Food & Nutrition Research is a peer-reviewed journal that presents the latest scientific research in various fields focusing on human nutrition. The journal publishes both quantitative and qualitative research papers. Through an Open Access publishing model, Food & Nutrition Research opens an important forum for researchers from academic and private arenas to exchange the latest results from research on human nutrition in a broad sense, both original papers and reviews, including: * Associations and effects of foods and nutrients on health * Dietary patterns and health * Molecular nutrition * Health claims on foods * Nutrition and cognitive functions * Nutritional effects of food composition and processing * Nutrition in developing countries * Animal and in vitro models with clear relevance for human nutrition * Nutrition and the Environment * Food and Nutrition Education * Nutrition and Economics Research papers on food chemistry (focus on chemical composition and analysis of foods) are generally not considered eligible, unless the results have a clear impact on human nutrition. The journal focuses on the different aspects of nutrition for people involved in nutrition research such as Dentists, Dieticians, Medical doctors, Nutritionists, Teachers, Journalists and Manufacturers in the food and pharmaceutical industries.