Enhancing oscillatory dysfunctome in aphasia: Phase-dependent network effects of connectomic transcranial alternating current stimulation

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI:10.1016/j.clinph.2026.2111712

Chester Yee-Nok Cheung, Anthony Pak-Hin Kong

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引用次数: 0

Abstract

Objective

Connectomic transcranial alternating current stimulation (tACS) utilizes connectomic model to guide network-modulating tACS. Early application of connectomic tACS supported the feasibility of using phase-synchronization tACS to modulate connectivity within a symptom-predictive subnetwork (a.k.a. dysfunctome) to promote clinical benefit in post-stroke aphasia (PSA). However, the dysfunctome-modulatory patterns of in/anti-phase tACS remain unclear. This study investigates the dysfunctome-enhancing effects of in/anti-phase tACS applied to a centralized edge within the dysfunctome, and how individualized targeting pinpointing an individual’s weakened edge, may moderate these effects.

Methods

Nine individuals with PSA received single-session, double-blinded, 10-Hz tACS paired with speech therapy under five within-subject conditions: Generalized In-phase (GI), Generalized Anti-phase (GA), Individualized In-phase (II), Individualized Anti-phase (IA), and sham. Generalized conditions targeted an edge with the highest centrality within the dysfunctome that is universal to all participants. Individualized conditions pinpointed a centralized-but-weakened edge based on the individual’s dysfunctome profile. Dysfunctome and overall network changes were compared.

Results

GI and IA had a medium effect with marginal significance in producing greater increase in average connectivity of the dysfunctome than sham. The reverse pattern of phase-dependent effect in generalized and individualized conditions suggests a moderator role of baseline connectivity of the target edge.

Conclusions

In-phase tACS could potentially promote a dysfunctome-wide enhancement when targeted at an undisrupted centralized edge. Anti-phase tACS was more effective when the individual’s disrupted centralized edge was targeted, possibly via network reorganization mechanism.

Significance

Immediate network-modulatory effects of tACS indicate potential for clinical applications in precision neurorehabilitation of PSA or other network-based disorders.

查看原文本刊更多论文

增强失语症的振荡功能障碍：经颅交流电流刺激的相位依赖网络效应。

目的：连接组经颅交流电刺激（tACS）利用连接组模型指导网络调节的tACS。连接组tACS的早期应用支持了使用相位同步tACS来调节症状预测子网络（又称功能障碍组）内的连通性以促进卒中后失语症（PSA）临床获益的可行性。然而，正相/反相tACS的功能失调组调节模式尚不清楚。本研究探讨了在功能障碍组内的集中边缘应用正相/反相tACS增强功能障碍组的效果，以及个性化靶向如何精确定位个体的减弱边缘，从而缓解这些影响。方法：9例PSA患者在5种受试者条件下接受单期、双盲、10hz tACS联合言语治疗：广义同期（GI）、广义反期（GA）、个体化同期（II）、个体化反期（IA）和假手术。广义条件的目标是在所有参与者普遍存在的功能障碍组中具有最高中心性的边缘。根据个体的功能障碍特征，个性化的条件确定了一个集中但减弱的边缘。比较功能障碍组和整体网络变化。结果：与假手术相比，GI和IA对功能障碍组平均连通性的增加有中等作用，但有边际意义。在广义和个性化条件下，相位依赖效应的反向模式表明目标边缘的基线连通性具有调节作用。结论：当靶向未中断的集中边缘时，同相tACS可能潜在地促进全功能障碍组增强。当可能通过网络重组机制针对个体的中断集中边缘时，反相tACS更有效。意义：tACS的即时网络调节作用表明其在PSA或其他基于网络的疾病的精确神经康复中的临床应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.