Reduced alpha-band phase coherence and cortical complexity in fibromyalgia: A tms-eeg exploratory study

IF 3.4 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-05-01 Epub Date: 2026-02-25 DOI:10.1016/j.clinph.2026.2111711

Anne Jakobsen , Enrico De Martino , Bruno A.N. Couto , Margit M. Bach , Stian Ingemann-Molden , Thorvaldur S. Palsson , Jakob Udby Blicher , Adenauer G. Casali , Thomas Graven-Nielsen , Daniel Ciampi de Andrade

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引用次数: 0

Abstract

Objectives

Cortico-spinal excitability of the primary motor cortex (M1) is reduced in fibromyalgia, and repetitive transcranial magnetic stimulation (TMS) targeting M1 normalizes these changes and relieves symptoms. TMS combined with electroencephalography (TMS-EEG) allows the measurement of M1 excitability and its connectivity to other regions, which may help clarify neurophysiological abnormalities in fibromyalgia. We assessed cortical excitability, oscillatory activity, and complexity in individuals with fibromyalgia compared to pain-free healthy controls.

Methods

Global- and local-mean field power, peak-to-peak amplitude, event-related spectral perturbation, intertrial coherence (ITC), natural frequency, and perturbational complexity index (PCIst) of the EEG response after left-M1 TMS were compared between groups (n = 18 fibromyalgia; n = 15 controls). Pain intensity, interference, current therapy, mood, and quality of life were assessed in individuals with fibromyalgia.

Results

Compared with controls, individuals with fibromyalgia showed a reduction in the alpha-band ITC in middle- (p = 0.044) and right-parieto-occipital areas (p = 0.040). Middle-parieto-occipital ITC negatively correlated with reported pain relief (rho = -0.552, p = 0.019). The PCIst was lower in fibromyalgia compared with controls (p = 0.009) and correlated with higher pain interference in general activity (rho = -0.486, p = 0.042).

Conclusion

Individuals with fibromyalgia have abnormal cortical connectivity compared with asymptomatic controls.

Significance

TMS-EEG may provide insights on brain connectivity relevant for prognostication and therapy in fibromyalgia.

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纤维肌痛的α带相位一致性和皮质复杂性降低：一项颅磁-脑电图探索性研究。

目的：纤维肌痛患者初级运动皮质（M1）的皮质-脊髓兴奋性降低，针对M1的重复经颅磁刺激（TMS）可使这些变化正常化并缓解症状。经颅磁刺激联合脑电图（TMS- eeg）可以测量M1兴奋性及其与其他区域的连接，这可能有助于阐明纤维肌痛的神经生理异常。我们评估了纤维肌痛患者与无痛健康对照者的皮质兴奋性、振荡活动和复杂性。方法：比较两组（18例纤维肌痛患者和15例对照组）左- m1经颅磁刺激后脑电反应的全局和局部平均场强、峰间振幅、事件相关谱摄动、试验间相干性（ITC）、固有频率和摄动复杂性指数（PCIst）。对纤维肌痛患者的疼痛强度、干扰、当前治疗、情绪和生活质量进行评估。结果：与对照组相比，纤维肌痛患者在中部（p = 0.044）和右侧顶枕区（p = 0.040）的α波段ITC降低。中顶枕ITC与报告的疼痛缓解呈负相关（rho = -0.552, p = 0.019）。与对照组相比，纤维肌痛症患者的PCIst较低（p = 0.009），并且与一般活动中较高的疼痛干扰相关（rho = -0.486, p = 0.042）。结论：与无症状对照相比，纤维肌痛患者的皮质连通性异常。意义：颅磁-脑电图可能为纤维肌痛的预后和治疗提供相关的脑连通性见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.