Ali Gheidari, Alireza Sarraf Shirazi, Iman Parisay, Mana Mowji
{"title":"Hydrophobic or hydrophilic fissure sealants: A systematic review and meta-analysis.","authors":"Ali Gheidari, Alireza Sarraf Shirazi, Iman Parisay, Mana Mowji","doi":"10.4103/drj.drj_358_25","DOIUrl":null,"url":null,"abstract":"<p><strong>Objectives: </strong>The objective of the study was to evaluate caries development and retention rate of resin-based hydrophilic and hydrophobic fissure sealants based on the randomized clinical trials in which the investigators have studied this subject.</p><p><strong>Materials and methods: </strong>A literature screen was conducted in some databases, including PubMed, Scopus, Embase, ISI Web of Science, and Cochrane Library, to select randomized clinical trials that compared the caries development/retention rate of resin-based hydrophilic and hydrophobic fissure sealants until March 2025. The risk of bias of the included studies was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2), and the meta-analysis was performed using a random-effect model. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.</p><p><strong>Results: </strong>A total of 20,945 articles were initially retrieved for screening, and fourteen studies were identified as eligible for inclusion in the quantitative analysis. The RoB assessment showed a high risk of bias in 5 studies, some concerns in 5, and low risk in 4. Caries development was reported in 11 studies, and retention rate in 14. The meta-analysis results showed a statistically significant difference for caries development (odds ratio [OR]: 0.490, 95% confidence interval [CI]: 0.277-0.867; <i>P</i> = 0.014), whereas the retention rate (OR: 0.859, 95% CI: 0.596-1.237; <i>P</i> = 0.414) indicated no statistically significant differences. The quality of evidence for both outcomes was rated as very low according to the GRADE system.</p><p><strong>Conclusion: </strong>It could be concluded that hydrophilic and hydrophobic resin-based fissure sealants are approximately equal in caries development and retention rate, with very low quality of evidence.</p><p><strong>Clinical relevance: </strong>In clinical practice, resin-based hydrophilic fissure sealants could be applied on susceptible tooth surfaces; in case of difficult isolation, with an almost equal clinical success for hydrophobic fissure sealants.</p>","PeriodicalId":11016,"journal":{"name":"Dental Research Journal","volume":"23 ","pages":"6"},"PeriodicalIF":0.0000,"publicationDate":"2026-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12952550/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Dental Research Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/drj.drj_358_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"Dentistry","Score":null,"Total":0}
引用次数: 0
Abstract
Objectives: The objective of the study was to evaluate caries development and retention rate of resin-based hydrophilic and hydrophobic fissure sealants based on the randomized clinical trials in which the investigators have studied this subject.
Materials and methods: A literature screen was conducted in some databases, including PubMed, Scopus, Embase, ISI Web of Science, and Cochrane Library, to select randomized clinical trials that compared the caries development/retention rate of resin-based hydrophilic and hydrophobic fissure sealants until March 2025. The risk of bias of the included studies was assessed using version 2 of the Cochrane risk-of-bias tool for randomized trials (RoB 2), and the meta-analysis was performed using a random-effect model. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach.
Results: A total of 20,945 articles were initially retrieved for screening, and fourteen studies were identified as eligible for inclusion in the quantitative analysis. The RoB assessment showed a high risk of bias in 5 studies, some concerns in 5, and low risk in 4. Caries development was reported in 11 studies, and retention rate in 14. The meta-analysis results showed a statistically significant difference for caries development (odds ratio [OR]: 0.490, 95% confidence interval [CI]: 0.277-0.867; P = 0.014), whereas the retention rate (OR: 0.859, 95% CI: 0.596-1.237; P = 0.414) indicated no statistically significant differences. The quality of evidence for both outcomes was rated as very low according to the GRADE system.
Conclusion: It could be concluded that hydrophilic and hydrophobic resin-based fissure sealants are approximately equal in caries development and retention rate, with very low quality of evidence.
Clinical relevance: In clinical practice, resin-based hydrophilic fissure sealants could be applied on susceptible tooth surfaces; in case of difficult isolation, with an almost equal clinical success for hydrophobic fissure sealants.
期刊介绍：
Dental Research Journal, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online journal with Bimonthly print on demand compilation of issues published. The journal’s full text is available online at http://www.drjjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository. The journal will cover technical and clinical studies related to health, ethical and social issues in field of Dentistry. Articles with clinical interest and implications will be given preference.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
