Low-volume collection devices for longitudinal biomarker monitoring in patient-centric sampling settings.

IF 1.8 4区医学 Q3 BIOCHEMICAL RESEARCH METHODS

Bioanalysis Pub Date : 2026-01-01 Epub Date: 2026-03-04 DOI:10.1080/17576180.2026.2635921

Szabolcs Simon-Guth, Ellinor Hedberg, Niclas Roxhed

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引用次数: 0

Abstract

Advances in analytical techniques now enable biomarker detection from sample volumes as small as one microliter, reducing the need for large-volume specimen collection. This capability has supported the development of low-volume blood collection devices that allow frequent, longitudinal sampling outside traditional healthcare facilities, promoting decentralized and patient-centered sampling (PCS). The development of user-friendly, at-home sampling devices with reduced invasiveness and minimized sampling discomfort further enhances participant recruitment and retention in long-term longitudinal studies. These longitudinal studies are essential for tracking disease progression, uncovering molecular mechanisms underlying disease, and gaining insights into how external stimuli, such as diet, medication and physical activity, affect physiological responses. In this review, we highlight current low-volume sampling technologies and their role in longitudinal PCS environments, alongside biomarker detection assays for small-volume specimens.

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在以患者为中心的采样设置中用于纵向生物标志物监测的小容量收集装置。

分析技术的进步现在可以从小到一微升的样品中检测生物标志物，减少了对大体积标本采集的需求。这种能力支持了小容量血液采集设备的开发，这些设备允许在传统医疗机构之外进行频繁的纵向采样，促进了分散和以患者为中心的采样（PCS）。用户友好的家用采样设备的发展，减少了侵入性和最小化采样不适，进一步提高了长期纵向研究中参与者的招募和保留。这些纵向研究对于追踪疾病进展、揭示疾病的分子机制以及了解外部刺激（如饮食、药物和身体活动）如何影响生理反应至关重要。在这篇综述中，我们重点介绍了当前的小体积采样技术及其在纵向PCS环境中的作用，以及小体积标本的生物标志物检测分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioanalysis BIOCHEMICAL RESEARCH METHODS-CHEMISTRY, ANALYTICAL

CiteScore

3.30

自引率

16.70%

发文量

审稿时长

2 months

期刊介绍： Reliable data obtained from selective, sensitive and reproducible analysis of xenobiotics and biotics in biological samples is a fundamental and crucial part of every successful drug development program. The same principles can also apply to many other areas of research such as forensic science, toxicology and sports doping testing. The bioanalytical field incorporates sophisticated techniques linking sample preparation and advanced separations with MS and NMR detection systems, automation and robotics. Standards set by regulatory bodies regarding method development and validation increasingly define the boundaries between speed and quality. Bioanalysis is a progressive discipline for which the future holds many exciting opportunities to further reduce sample volumes, analysis cost and environmental impact, as well as to improve sensitivity, specificity, accuracy, efficiency, assay throughput, data quality, data handling and processing. The journal Bioanalysis focuses on the techniques and methods used for the detection or quantitative study of analytes in human or animal biological samples. Bioanalysis encourages the submission of articles describing forward-looking applications, including biosensors, microfluidics, miniaturized analytical devices, and new hyphenated and multi-dimensional techniques. Bioanalysis delivers essential information in concise, at-a-glance article formats. Key advances in the field are reported and analyzed by international experts, providing an authoritative but accessible forum for the modern bioanalyst.