Consequence of malaria and dengue on reproductive vigor. A scoping review.

Q2 Medicine

Clinica Terapeutica Pub Date : 2026-03-01 DOI:10.7417/CT.2026.2016

Pratik Kumar Chatterjee, Poulomi Chatterjee, Babi Dutta, N Anupama, Mythri R, Swati Dhar, Rashmi Ks, Shilpa N Bijoor, Akash Tomar, Aparna Tripathy

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引用次数: 0

Abstract

Backgroundv: Malaria is associated with decreased semen quality, oligozoospermia, necrozoo-spermia/azoospermia. Antimalarial-drugs have adverse-effects on re¬productive functions. (40-90) % of male infertility is due to scarce sperm production of obscure source. This review was undertaken to understand the effects of malaria/dengue and antimalarial drugs on reproductive health.

Methodology: A broad systematic exploration was steered, using electronic databases, limiting to articles (English) using words- "Infertility", "Malaria", "Preterm birth", "Dengue" etc., (2013-2024), to identify relevant studies.

Results: Malaria causes decreased semen quality in men; higher rates of miscarriage, intrauterine demise, premature delivery, LBW, neonatal deaths, anemia and maternal deaths in pregnancy. Antimalarial-drugs (chloroquine, quinine, quinacrine, pyrimethamine) cause male infertility. Acute dengue infection leads to temporary alterations in sperm but not long-term infertility; during pregnancy it causes an increased risk of premature delivery, fetal death, and hemorrhagic complications.

Conclusion: Malaria/dengue affect reproductive health in humans, indirect effect being infertility due to antimalarial-drugs.

查看原文本刊更多论文

疟疾和登革热对生殖活力的影响。范围审查。

背景：疟疾与精液质量下降、少精子症、坏死性精子症/无精子症有关。抗疟药物对生殖功能有不利影响。（40- 90%） %的男性不育症是由于精子来源不明导致的。进行这项审查是为了了解疟疾/登革热和抗疟疾药物对生殖健康的影响。方法：采用电子数据库进行广泛的系统探索，限于2013-2024年使用“不孕不育”，“疟疾”，“早产”，“登革热”等词的文章（英文），以识别相关研究。结果：疟疾导致男性精液质量下降；流产、宫内死亡、早产、低体重、新生儿死亡、贫血和孕妇死亡的比率较高。抗疟药物（氯喹、奎宁、奎宁、乙胺嘧啶）会导致男性不育。急性登革热感染导致精子暂时改变，但不会导致长期不育；在怀孕期间，它会增加早产、胎儿死亡和出血性并发症的风险。结论：疟疾/登革热影响人类生殖健康，间接影响是抗疟药物导致的不育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinica Terapeutica PHARMACOLOGY & PHARMACY-

CiteScore

2.50

自引率

0.00%

发文量

124

审稿时长

6-12 weeks

期刊介绍： La Clinica Terapeutica è una rivista di Clinica e Terapia in Medicina e Chirurgia, fondata nel 1951 dal Prof. Mariano Messini (1901-1980), Direttore dell''Istituto di Idrologia Medica dell''Università di Roma “La Sapienza”. La rivista è pubblicata come “periodico bimestrale” dalla Società Editrice Universo, casa editrice fondata nel 1945 dal Comm. Luigi Pellino. La Clinica Terapeutica è indicizzata su MEDLINE, INDEX MEDICUS, EMBASE/Excerpta Medica.