Association of the C-Reactive Protein-Albumin-Lymphocyte Index with Chronic Kidney Disease: A Comprehensive Assessment Based on Inflammation, Nutrition, and Immune Status.

IF 2.1 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Kidney & blood pressure research Pub Date : 2026-01-01 Epub Date: 2026-03-02 DOI:10.1159/000551082

Xiujun Zhang, Fan Zhang, Wenjian Li

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引用次数: 0

Abstract

Introduction: This study aimed to examine the relationship between the C-reactive protein-albumin-lymphocyte (CALLY) index, a composite measure of inflammation, nutritional status, and immune function, and chronic kidney disease (CKD).

Methods: The study employed a population-based cohort retrospective analysis design, integrating the NHANES dataset (n = 24,538) and the clinical cohort of China (n = 7,102). The present study sought to assess the association and predictive efficacy of the CALLY index for CKD. To this end, multistage logistic regression modeling, receiver operating characteristic (ROC) analysis, and restricted cubic spline analysis were employed. The analysis controlled for demographic factors, lifestyle, and metabolic diseases.

Results: The study indicated a negative correlation between the CALLY index and CKD, with a 1% reduction (odds ratio [OR] = 0.99, 95% confidence interval [CI] = 0.99-0.99) and a 3% reduction (OR = 0.97, 95% CI = 0.96-0.98) in CKD risk for every 1-unit increase in the index, respectively, in the US and Chinese cohorts. The ROC analyses yielded a multifactorial-adjusted AUC for the US cohort of 0.803 (95% CI: 0.795-0.810), and the Chinese cohort was 0.676 (95% CI: 0.657-0.695). Threshold effect analyses demonstrated that the risk significantly reduced when CALLY<2.313 (OR = 0.77 for the US cohort and OR = 0.63 for the Chinese cohort), and the association disappeared above the threshold. Subgroup analyses indicated that hypertension and obesity status modified the predictive efficacy of the CALLY index.

Conclusion: The CALLY index demonstrates a negative correlation with CKD. Its cross-cohort robustness and threshold effect provide a foundation for implementing early screening and stratified intervention strategies. However, the index's clinical translational value remains to be validated in future studies.

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c反应蛋白-白蛋白淋巴细胞指数与慢性肾脏疾病的关联：基于炎症、营养和免疫状态的综合评估

目的：本研究旨在探讨c反应蛋白-白蛋白淋巴细胞（CALLY）指数与慢性肾脏疾病（CKD）之间的关系。CALLY指数是一种综合衡量炎症、营养状况和免疫功能的指标。方法：采用基于人群的队列回顾性分析设计，整合NHANES数据集（n = 24,538）和中国临床队列（n = 7,102）。本研究旨在评估CALLY指数与CKD的相关性和预测功效。为此，采用多阶段logistic回归模型、受试者工作特征（ROC）分析和受限三次样条（RCS）分析。分析控制了人口因素、生活方式和代谢性疾病。结果：研究表明CALLY指数与CKD之间呈负相关，在美国和中国队列中，CALLY指数每增加1个单位，CKD风险分别降低1%(优势比（OR) = 0.99, 95%可信区间(CI) = 0.99-0.99）和3% （OR = 0.97, 95% CI = 0.96-0.98）。ROC分析得出美国队列的多因素校正AUC为0.803 (95% CI: 0.795-0.810)，中国队列为0.676 （95% CI: 0.657-0.695）。阈值效应分析表明，当CALLY指数与CKD呈负相关时，风险显著降低。其跨队列稳健性和阈值效应为实施早期筛查和分层干预策略提供了基础。然而，该指标的临床转化价值还有待于进一步的研究验证。

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来源期刊

Kidney & blood pressure research 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This journal comprises both clinical and basic studies at the interface of nephrology, hypertension and cardiovascular research. The topics to be covered include the structural organization and biochemistry of the normal and diseased kidney, the molecular biology of transporters, the physiology and pathophysiology of glomerular filtration and tubular transport, endothelial and vascular smooth muscle cell function and blood pressure control, as well as water, electrolyte and mineral metabolism. Also discussed are the (patho)physiology and (patho) biochemistry of renal hormones, the molecular biology, genetics and clinical course of renal disease and hypertension, the renal elimination, action and clinical use of drugs, as well as dialysis and transplantation. Featuring peer-reviewed original papers, editorials translating basic science into patient-oriented research and disease, in depth reviews, and regular special topic sections, ''Kidney & Blood Pressure Research'' is an important source of information for researchers in nephrology and cardiovascular medicine.