High-Resolution Ultrasonography for Detecting Peripheral Neuropathy in Leprosy: A Systematic Review and Meta-Analysis.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Journal of Clinical Neurophysiology Pub Date : 2026-03-01 DOI:10.1097/WNP.0000000000001229

Sara Ahmed Metwally, Shahd Al Haj Ali, Mostafa Tantawy, Nehal Ataky, Karim Mohamed Eltaib, Mohamed Emam Elatrosh, Horiah Amer Al-Ghorbany, Alamin Awadallah Mohamed Magzoub, Baraah Abd-Alqader Ibraheem Mdalal, Ahmed Medhat Helmy Hussein, Khaled Ashraf Mohamed, Mohamed A Bedewi, Ezzat M Awad

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引用次数: 0

Abstract

Background: Leprosy is a chronic granulomatous disease that commonly affects the peripheral nervous system, often leading to significant disability. High-resolution ultrasonography has emerged as a promising tool for the noninvasive assessment of nerve involvement in leprosy.

Objective: To figure out the diagnostic value of HRUS in assessing peripheral nerve involvement in leprosy, with a focus on measuring the cross-sectional area (CSA) of major nerves.

Methods: A systematic search of PubMed, Scopus, Web of Science, and Embase was conducted up to 2024. Seventeen studies were included, and quality assessment was performed using NIH and NOS tools. Meta-analyses compared CSA of the ulnar, median, posterior tibial, and common fibular nerves between patients with leprosy and healthy controls. Heterogeneity was evaluated using the I2 statistic and sensitivity analyses were performed.

Results: Patients with leprosy showed significantly increased CSA in all examined nerves compared with controls. Single-arm analysis of CSA in patients with leprosy showed consistent nerve enlargement, particularly in the ulnar nerve.

Conclusions: Our review shows the usefulness of HRUS as a sensitive, noninvasive imaging modality for evaluating peripheral nerve involvement in leprosy.

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高分辨率超声检查麻风病周围神经病变：系统回顾和荟萃分析。

背景：麻风病是一种慢性肉芽肿性疾病，通常影响周围神经系统，常导致严重残疾。高分辨率超声检查已成为一种有前途的工具，用于无创评估麻风病的神经受累。目的：探讨HRUS在评估麻风病周围神经受累中的诊断价值，重点是测量主要神经的横截面积（CSA）。方法：系统检索PubMed、Scopus、Web of Science、Embase数据库至2024年。纳入17项研究，使用NIH和NOS工具进行质量评估。meta分析比较了麻风病患者和健康对照者尺神经、正中神经、胫后神经和腓骨总神经的CSA。采用I2统计量评估异质性，并进行敏感性分析。结果：与对照组相比，麻风病患者所有检查神经的CSA均明显增加。麻风病患者单臂CSA分析显示神经持续增大，尤其是尺神经。结论：我们的综述显示HRUS作为一种敏感的、无创的成像方式用于评估麻风病周围神经受累。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Clinical Neurophysiology 医学-临床神经学

CiteScore

4.60

自引率

4.20%

发文量

198

审稿时长

6-12 weeks

期刊介绍： The Journal of Clinical Neurophysiology features both topical reviews and original research in both central and peripheral neurophysiology, as related to patient evaluation and treatment. Official Journal of the American Clinical Neurophysiology Society.