The effect of a novel bone bioactive oral rinse (Theravex) on early soft-tissue wound healing following simple tooth extraction in patients with type 2 diabetes mellitus: A prospective comparative clinical study.

Abstract

Objective: The aim of the study was to assess the effectiveness of bone bioactive rinse in promoting early wound healing following simple tooth extraction in diabetic patients.

Materials and methods: A prospective comparative study was conducted at King Abdulaziz University Dental Hospital between March and May 2025. The study included 48 diabetic patients undergoing simple tooth extractions. Patients were assigned to either a test group (n=28) that used a bone bioactive rinse or a control group (n=20) that received no intervention. Healing was assessed on days 5 and 14 using a modified Early Healing Index (scale 1-5).

Results: A total of 48 diabetic patients (mean age: 51.25 ± 11.8 years) were enrolled into the bone bioactive rinse group (n=28) and the control group (n=20). While socket dimension measurements (width, height, area) were not significantly different between groups at either day 5 or 2 weeks post-extraction (p > 0.05), the clinical healing index showed a marked difference. On day 5, 96.4% of patients in the rinse group achieved a 'very good' healing score, compared to only 5% in the control group (p < 0.001). By week 2, 100% of the test group maintained high healing scores, vs. 20% in the control group (p < 0.001). No significant gender-related differences in healing outcomes were observed (p > 0.3).

Conclusions: Bone bioactive rinse significantly enhances early wound healing after tooth extraction in diabetic patients and may serve as a valuable adjunct in clinical practice.