{"title":"Role of Gut Microbiota in Immune Checkpoint Inhibitor Therapy","authors":"Yue-Chun Fu, Bing Pang, Shao-Bo Liang","doi":"10.1002/cbin.70148","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>Immune checkpoint inhibitors (ICIs), which have become the primary treatment of carcinomas in recent years, not only bring survival benefits to patients, but also come with various side effects. Studies have shown that different gut microbiota groups have different effects on the efficacy and side effects of ICIs. Here, we summarize the relevant research progress on gut microbiota and the efficacy and side effects of ICIs, explore the mechanisms of the gut microbiota in modulating anticancer immunotherapy and further discuss treatment strategies of how the gut microbiota enhancing the efficacy and reducing side effects of ICIs. This study aims to identify specific gut microbiota as potential biomarkers for ICI treatment to screen for patients who may respond effectively to ICI treatment, thereby improving efficacy and mitigating side effects.</p></div>","PeriodicalId":9806,"journal":{"name":"Cell Biology International","volume":"50 3","pages":""},"PeriodicalIF":3.1000,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell Biology International","FirstCategoryId":"99","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbin.70148","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
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Abstract
Immune checkpoint inhibitors (ICIs), which have become the primary treatment of carcinomas in recent years, not only bring survival benefits to patients, but also come with various side effects. Studies have shown that different gut microbiota groups have different effects on the efficacy and side effects of ICIs. Here, we summarize the relevant research progress on gut microbiota and the efficacy and side effects of ICIs, explore the mechanisms of the gut microbiota in modulating anticancer immunotherapy and further discuss treatment strategies of how the gut microbiota enhancing the efficacy and reducing side effects of ICIs. This study aims to identify specific gut microbiota as potential biomarkers for ICI treatment to screen for patients who may respond effectively to ICI treatment, thereby improving efficacy and mitigating side effects.
期刊介绍：
Each month, the journal publishes easy-to-assimilate, up-to-the minute reports of experimental findings by researchers using a wide range of the latest techniques. Promoting the aims of cell biologists worldwide, papers reporting on structure and function - especially where they relate to the physiology of the whole cell - are strongly encouraged. Molecular biology is welcome, as long as articles report findings that are seen in the wider context of cell biology. In covering all areas of the cell, the journal is both appealing and accessible to a broad audience. Authors whose papers do not appeal to cell biologists in general because their topic is too specialized (e.g. infectious microbes, protozoology) are recommended to send them to more relevant journals. Papers reporting whole animal studies or work more suited to a medical journal, e.g. histopathological studies or clinical immunology, are unlikely to be accepted, unless they are fully focused on some important cellular aspect.
These last remarks extend particularly to papers on cancer. Unless firmly based on some deeper cellular or molecular biological principle, papers that are highly specialized in this field, with limited appeal to cell biologists at large, should be directed towards journals devoted to cancer, there being very many from which to choose.
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