Brief pharmacist-led intervention using a structured questionnaire to improve attitudes toward medication adherence in patients on antipsychotics: a single-site before-after study.

IF 5.8 3区医学 Q1 PSYCHIATRY

Annals of General Psychiatry Pub Date : 2026-03-03 DOI:10.1186/s12991-026-00636-7

Masaki Maehara, Masayasu Sugiyama, Daisuke Kobayashi, Junpei Mutoh, Kanta Noguchi, Mitsuhiro Wada

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Abstract

Background: Medication adherence among patients with psychiatric disorders is a significant challenge that often leads to poor clinical outcomes. Although pharmacist-led interventions have demonstrated the potential to improve medication adherence, evidence remains limited, particularly in patients treated with antipsychotics. This study aimed to evaluate the effectiveness of a brief pharmacist-led intervention in enhancing medication adherence among outpatients receiving antipsychotic therapy.

Methods: This exploratory, prospective, single-arm study was conducted at a community pharmacy in Japan. Fifty outpatients prescribed antipsychotic medications participated in the study. A brief pharmacist-led intervention was delivered focusing on identifying and addressing barriers to adherence. The primary outcomes were changes in Drug Attitude Inventory-10 (DAI-10) scores and the proportion of participants with unused medications.

Results: Participants taking preexisting medications exhibited a significant improvement in DAI-10 scores (mean increase, + 2.05 points; from 5.81 ± 4.00 to 7.86 ± 2.90, p = 0.00619). The proportion of participants who reported non-adherence to medication regimens decreased significantly from 42% to 24% (p= 0.0159).

Conclusions: The brief pharmacist-led intervention was effective in improving attitudes toward medication and behavioral adherence among patients receiving antipsychotic treatment in our study group. These findings underscore the importance of active pharmacist engagement for supporting medication adherence.

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简短的药剂师主导的干预，使用结构化问卷，以改善抗精神病药物患者对药物依从性的态度：一项单点前后研究。

背景：精神障碍患者的药物依从性是一个重大挑战，往往导致不良的临床结果。尽管药剂师主导的干预措施已经证明有可能改善药物依从性，但证据仍然有限，特别是在接受抗精神病药物治疗的患者中。本研究旨在评估一个简短的药剂师主导的干预措施在提高门诊接受抗精神病药物治疗的患者的药物依从性方面的有效性。方法：这项探索性、前瞻性、单臂研究在日本一家社区药房进行。50名接受抗精神病药物治疗的门诊患者参与了这项研究。一个简短的药剂师主导的干预措施，重点是识别和解决依从性的障碍。主要结果是药物态度量表-10 （DAI-10）得分的变化和未使用药物的参与者比例的变化。结果：服用既往药物的受试者DAI-10评分有显著改善（平均增加+ 2.05分；从5.81±4.00到7.86±2.90,p = 0.00619）。报告不遵守药物治疗方案的参与者比例从42%显著下降到24% （p= 0.0159）。结论：在我们的研究组中，药剂师主导的简短干预有效地改善了接受抗精神病药物治疗的患者对药物的态度和行为依从性。这些发现强调了积极的药剂师参与支持药物依从性的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of General Psychiatry PSYCHIATRY-

CiteScore

6.60

自引率

2.70%

发文量

审稿时长

>12 weeks

期刊介绍： Annals of General Psychiatry considers manuscripts on all aspects of psychiatry, including neuroscience and psychological medicine. Both basic and clinical neuroscience contributions are encouraged. Annals of General Psychiatry emphasizes a biopsychosocial approach to illness and health and strongly supports and follows the principles of evidence-based medicine. As an open access journal, Annals of General Psychiatry facilitates the worldwide distribution of high quality psychiatry and mental health research. The journal considers submissions on a wide range of topics including, but not limited to, psychopharmacology, forensic psychiatry, psychotic disorders, psychiatric genetics, and mood and anxiety disorders.