Adipose Depot Changes and Associated Metabolic Risk in the Longitudinal Health Influences of Puberty Study

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2026-03-02 DOI:10.1111/ijpo.70083

Catherine C. Cohen, Jaime M. Moore, Samantha Bothwell, Laura Pyle, Dan Lopez-Paniagua, Meredith A. Ware, Rachel Whooten, Philip S. Zeitler, Kristen J. Nadeau, Megan M. Kelsey

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引用次数: 0

Abstract

Objective

To assess longitudinal changes in abdominal subcutaneous and visceral adipose tissue (SAT and VAT), hepatic fat fraction (HFF) and pancreatic fat fraction (PFF) across puberty in youth with/without obesity and examine associations with cardiometabolic risk markers.

Methods

Within the Health Influences of Puberty (HIP) cohort, we included 19 participants (53% female, 37% obesity) who completed magnetic resonance imaging (MRI) at early (Tanner 2/3) and late (Tanner 4/5) puberty to assess abdominal SAT and VAT areas (cm²), HFF (%) and PFF (%). Cardiometabolic markers included glucose/insulin measures assessed by intravenous glucose tolerance test, fasting lipid panel and adipokines.

Results

From early to late puberty, among youth with obesity, median (interquartile range) abdominal SAT increased 83.1cm² (43.4) and, among youth without obesity, VAT/SAT ratio decreased −0.08 (0.08) and HFF increased 0.6% (0.5). In linear mixed models of adipose depots in early puberty and metabolic markers measured twice during puberty, adjusted for BMI group, abdominal SAT was positively associated with leptin β (95% confidence interval): 1.05 (0.35, 1.74), and VAT was positively associated with triglycerides 0.32 (0.02, 0.61) and high-sensitivity c-reactive protein (hsCRP) 1.40 (0.31, 2.49), while HFF was inversely associated with insulin sensitivity 0.32 (−0.58, −0.07) and PFF was inversely associated with adiponectin 0.23 (−0.42, −0.04) (all p < 0.05).

Conclusion

In this small sample, abdominal and ectopic fat depots in early puberty were uniquely associated with alterations in cardiometabolic risk markers during puberty.

Trial Registration: ClinicalTrials.gov identifier: NCT01775813

查看原文本刊更多论文

青春期纵向健康影响研究中的脂肪储备变化和相关代谢风险。

目的：评估有/无肥胖青少年青春期腹部皮下和内脏脂肪组织（SAT和VAT）、肝脏脂肪分数（HFF）和胰腺脂肪分数（PFF）的纵向变化，并研究其与心脏代谢危险标志物的关系。方法：在青春期健康影响（HIP）队列中，我们纳入了19名参与者（53%女性，37%肥胖），他们在青春期早期（Tanner 2/3）和后期（Tanner 4/5）完成了磁共振成像（MRI），以评估腹部SAT和VAT面积（cm2）， HFF（%）和PFF（%）。心脏代谢指标包括葡萄糖/胰岛素测量，通过静脉葡萄糖耐量试验，空腹脂质面板和脂肪因子评估。结果：青春期前期至后期，肥胖青少年腹部SAT中位数（四分位间距）增加83.1cm2(43.4)，非肥胖青少年VAT/SAT比值下降-0.08 (0.08)，HFF增加0.6%（0.5）。在青春期早期脂肪库的线性混合模型和青春期期间两次测量的代谢标志物中，调整BMI组，腹部SAT与瘦素β呈正相关（95%置信区间）：1.05 (0.35, 1.74)， VAT与甘油三酯0.32（0.02,0.61）和高敏c反应蛋白（hsCRP） 1.40（0.31, 2.49）呈正相关，HFF与胰岛素敏感性0.32（-0.58,-0.07）呈负相关，PFF与脂联素0.23（-0.42,-0.04）呈负相关（均为p）。结论：在这个小样本中，青春期早期腹部和异位脂肪库与青春期期间心脏代谢危险标志物的改变具有独特的相关性。试验注册：ClinicalTrials.gov标识符：NCT01775813。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.