Cyclodextrins as supramolecular agents for enhancing the separation performance of deep eutectic solvents: an overview of food and pharmaceutical applications

IF 1.6 4区化学 Q2 Agricultural and Biological Sciences

Journal of Inclusion Phenomena and Macrocyclic Chemistry Pub Date : 2025-12-20 DOI:10.1007/s10847-025-01323-y

Shima Saffarionpour

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引用次数: 0

Abstract

With the culmination of the research on the development of novel and green solvents in the separation industries, there has been a spurred interest recently in the development of cyclodextrin (CD)-based supramolecular deep eutectic solvents (DESs) or SUPRADES. The SUPRADESs prepared from CDs and carboxylic acids or the stimuli-responsive ones formulated with fatty acids can promote the separation of countless hydrophobic compounds among others polyphenols, terpenoids, or proteins from plant-based sources. Additionally, in combination with polymers (e.g. chitosan), SUPRADESs have been used for designing bioactive films. As chiral selectors, CDs added to DESs can contribute to the enantioseparation of chiral therapeutic compounds in capillary electrophoresis (CE) and electrokinetic chromatography (EKC). They can additionally aid with the enantiorecognition of chiral amino acids in biphasic systems. Given their efficacious roles in augmenting the separation and delivery performance of DESs, this review study enfolds their potential applications in the food and pharmaceutical industries.

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环糊精作为提高深共晶溶剂分离性能的超分子试剂：食品和制药应用综述

随着分离工业对新型绿色溶剂研究的不断深入，基于环糊精（CD）的超分子深共晶溶剂（DESs）或SUPRADES的研究引起了人们的极大兴趣。由CDs和羧酸制备的SUPRADESs或由脂肪酸配制的刺激反应性SUPRADESs可以促进无数疏水化合物的分离，其中包括来自植物源的多酚、萜类或蛋白质。此外，与聚合物（如壳聚糖）结合，SUPRADESs已用于设计生物活性膜。作为手性选择剂，添加到DESs中的CDs可以在毛细管电泳（CE）和电动色谱（EKC）中实现手性治疗化合物的对映体分离。它们还可以帮助双相系统中手性氨基酸的对映体识别。鉴于它们在提高DESs的分离和输送性能方面的有效作用，本文综述了它们在食品和制药工业中的潜在应用。

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来源期刊

Journal of Inclusion Phenomena and Macrocyclic Chemistry 化学-化学综合

CiteScore

3.30

自引率

8.70%

发文量

审稿时长

3-8 weeks

期刊介绍： The Journal of Inclusion Phenomena and Macrocyclic Chemistry is the premier interdisciplinary publication reporting on original research into all aspects of host-guest systems. Examples of specific areas of interest are: the preparation and characterization of new hosts and new host-guest systems, especially those involving macrocyclic ligands; crystallographic, spectroscopic, thermodynamic and theoretical studies; applications in chromatography and inclusion polymerization; enzyme modelling; molecular recognition and catalysis by inclusion compounds; intercalates in biological and non-biological systems, cyclodextrin complexes and their applications in the agriculture, flavoring, food and pharmaceutical industries; synthesis, characterization and applications of zeolites. The journal publishes primarily reports of original research and preliminary communications, provided the latter represent a significant advance in the understanding of inclusion science. Critical reviews dealing with recent advances in the field are a periodic feature of the journal.