{"title":"Two novel benzotriazole Cu(II) complexes: synthesis, structure and antidiabetic activity","authors":"Xia Wang, Han-Bing Li, Di Cheng, Meng-Meng Cao, Wen-Ke Yang, Tan-Peng Zhou","doi":"10.1007/s11243-025-00708-9","DOIUrl":null,"url":null,"abstract":"<div><p>Two novel benzotriazole Cu(II) complexes, [Cu(bmem)(CH<sub>3</sub>O)Cl]<sub>n</sub> (<b>1</b>) and [Cu(btmt)(H<sub>2</sub>O)(SO<sub>4</sub>)]<sub>2</sub> (<b>2</b>), were synthesized and characterized using 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole) (bmem) and 1-(benzotriazole-1-methyl)-1-triazole (btmt) as ligands. X-ray single crystal diffraction analysis indicates that complex <b>1</b> forms a one-dimensional chain structure of a double-nuclear copper unit, while complex <b>2</b> forms a discrete binuclear copper unit. Their antidiabetic activities were thoroughly investigated. The antidiabetic activity assays demonstrated that both complexes exhibited inhibitory effects against α-amylase and α-glycosidase enzymes. Specifically, complex <b>1</b> showed IC<sub>50</sub> values of 2.92 × 10<sup>− 3</sup> M for α-amylase and 2.39 × 10<sup>− 6</sup> M for α-glycosidase, while complex <b>2</b> exhibited IC<sub>50</sub> values of 1.89 × 10<sup>− 3</sup> M and 1.63 × 10<sup>− 6</sup> M, respectively, with complex <b>2</b> displaying a stronger inhibitory effect overall. Furthermore, to evaluate the effects of complexes <b>1</b> and <b>2</b> on glucose metabolism, we treated insulin-resistant (IR) HepG2 cells with each complex. The results demonstrated that complexes <b>1</b> and <b>2</b> enhanced glucose uptake by 1.20-fold and 1.32-fold, respectively, compared to the untreated control.</p></div>","PeriodicalId":803,"journal":{"name":"Transition Metal Chemistry","volume":"51 2","pages":""},"PeriodicalIF":2.8000,"publicationDate":"2026-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Transition Metal Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1007/s11243-025-00708-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
Two novel benzotriazole Cu(II) complexes, [Cu(bmem)(CH3O)Cl]n (1) and [Cu(btmt)(H2O)(SO4)]2 (2), were synthesized and characterized using 1-(benzotriazole-1-methyl)-1-(2-ethylimidazole) (bmem) and 1-(benzotriazole-1-methyl)-1-triazole (btmt) as ligands. X-ray single crystal diffraction analysis indicates that complex 1 forms a one-dimensional chain structure of a double-nuclear copper unit, while complex 2 forms a discrete binuclear copper unit. Their antidiabetic activities were thoroughly investigated. The antidiabetic activity assays demonstrated that both complexes exhibited inhibitory effects against α-amylase and α-glycosidase enzymes. Specifically, complex 1 showed IC50 values of 2.92 × 10− 3 M for α-amylase and 2.39 × 10− 6 M for α-glycosidase, while complex 2 exhibited IC50 values of 1.89 × 10− 3 M and 1.63 × 10− 6 M, respectively, with complex 2 displaying a stronger inhibitory effect overall. Furthermore, to evaluate the effects of complexes 1 and 2 on glucose metabolism, we treated insulin-resistant (IR) HepG2 cells with each complex. The results demonstrated that complexes 1 and 2 enhanced glucose uptake by 1.20-fold and 1.32-fold, respectively, compared to the untreated control.
期刊介绍：
Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc.
Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.
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