Biological Activity of Quaternary Ammonium Salts Containing a 1,3-Dioxacycloalkane or a gem-Dichlorocyclopropane Moieties

IF 0.7 4区化学 Q4 CHEMISTRY, APPLIED

Russian Journal of Applied Chemistry Pub Date : 2026-02-12 DOI:10.1134/S107042722512002X

G. Z. Raskil’dina, Yu. G. Borisova, A. N. Vereshchagin, E. V. Detusheva, R. M. Sultanova, S. S. Zlotskii

引用次数: 0

Abstract

Quaternary ammonium salts (QAS) containing gem-dichlorocyclopropane and 1,3-dioxacycloalkane moieties were synthesized (40–90% yields) based on pyridine, hexamethylenetetramine, and tertiary amines. The structure of the obtained salts was confirmed by ¹H and ¹³C NMR spectroscopy data. The antibacterial activity of the QAS against bacterial strains (Escherichia coli, Klebsiella pneumoniae, S. aureus, and Acinetobacter baumannii) was evaluated. The study showed that among the series of salts there are “leader” compounds exhibiting high antibacterial activity.

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含有1,3-二氧环烷或宝石-二氯环丙烷基团的季铵盐的生物活性

以吡啶、六亚甲基四胺和叔胺为原料合成了含有宝石-二氯环丙烷和1,3-二氧环烷烃的季铵盐（QAS），产率为40-90%。所得盐的结构经1H和13C核磁共振谱数据证实。评价了QAS对大肠埃希菌、肺炎克雷伯菌、金黄色葡萄球菌和鲍曼不动杆菌的抗菌活性。研究表明，在该系列盐中存在具有较高抗菌活性的先导化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Russian Journal of Applied Chemistry 化学-应用化学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

2-4 weeks

期刊介绍： Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.