Synthesis, Characterization, and Evaluation of Biological Activity of Dihydroquinazoline-4-one and 1,3-Benzothiazine-4-one Derivatives

IF 0.7 4区化学 Q4 CHEMISTRY, APPLIED

Russian Journal of Applied Chemistry Pub Date : 2026-02-12 DOI:10.1134/S1070427225600956

Wasan K. Damdoom, Oday H. R. Al-Jeilawi, Maha D. Azeez

引用次数: 0

Abstract

Six membered heterocyclic derivatives (dihydroquinazoline-4-one and 1,3-benzothiazine-4-one (6–15)) were synthesized by cyclization reaction of Schiff bases (1–5) with anthranilic acid and o-mercaptobenzoic acid in oily bath. Prepared compounds was characterized by FTIR, ¹H NMR, ¹³C NMR, mass spectroscopy and elemental analysis to confirm structure of synthesized derivatives. Heterocyclic compounds are of interest for scientific research due to important antioxidant properties; Compounds 10, 12, and 15 appeared good results by scavenging free radicals. Investigation of microbial activity to synthesized compounds 6–15 showed that compounds 6, 10, and 11 demonstrate the highest inhibition zone.

Abstract Image

查看原文本刊更多论文

二氢喹唑啉-4- 1和1,3-苯并噻嗪-4- 1衍生物的合成、表征及生物活性评价

采用希夫碱（1 - 5）与邻氨基苯甲酸和邻巯基苯甲酸在油浴中进行环化反应，合成了六元杂环衍生物二氢喹唑啉-4- 1和1,3-苯并噻唑-4- 1（6-15）。用FTIR、1H NMR、13C NMR、质谱和元素分析等手段对合成的化合物进行了表征。杂环化合物因其重要的抗氧化性能而受到科学研究的关注；化合物10、12、15具有良好的自由基清除效果。对合成的化合物6 ~ 15的抑菌活性研究表明，化合物6、10和11的抑菌带最高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Russian Journal of Applied Chemistry 化学-应用化学

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

2-4 weeks

期刊介绍： Russian Journal of Applied Chemistry (Zhurnal prikladnoi khimii) was founded in 1928. It covers all application problems of modern chemistry, including the structure of inorganic and organic compounds, kinetics and mechanisms of chemical reactions, problems of chemical processes and apparatus, borderline problems of chemistry, and applied research.