Three naphthomycin type polyketide compounds isolated from strain Streptomyces sp. HKIB0008

IF 5.8 3区化学 Q1 CHEMISTRY, MEDICINAL

Natural Products and Bioprospecting Pub Date : 2026-03-03 DOI:10.1007/s13659-026-00591-6

Yuan Chen, Fei Zhang, Zi-Kang Zhao, Lin-Fang Tang, Yu-Xin Sun, Mi-Mi Tian, Xing-Tao Li, Qian Zhao, Xiao-Jiang Hao, Mingming Cao, Duozhi Chen

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Abstract

Three new naphthomycin derivatives were isolated and identified from Streptomyces sp. HKIB0008, and were designated as naphthomycin R (1), naphthomycin S (2), and naphthomycin T (3). Their structures were elucidated using a combination of spectroscopic techniques, including high-resolution mass spectrometry, and NMR. The naphthoquinone core of 1 underwent carbon–carbon bond cleavage, resulting in a novel structural feature, and a corresponding Baeyer–Villiger oxidation mechanism was proposed. Compounds 2 and 3 possess a complex side chain when compared to known cystine modification on the naphthalenoid core as in the case of naphthomycins I and J. In addition, the minimum inhibitory concentration (MIC) assays for these compounds were conducted.

Graphical Abstract

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从Streptomyces sp. HKIB0008中分离得到3个萘霉素型聚酮化合物

从Streptomyces sp. HKIB0008中分离鉴定了3个新的萘霉素衍生物，分别命名为萘霉素R(1)、萘霉素S(2)和萘霉素T(3)。它们的结构是通过结合光谱技术，包括高分辨率质谱和核磁共振来阐明的。1的萘醌核发生碳-碳键断裂，形成新的结构特征，并提出了相应的Baeyer-Villiger氧化机制。化合物2和3具有一个复杂的侧链，与已知的在类萘核心上的胱氨酸修饰相比，如萘霉素I和j。此外，对这些化合物进行了最低抑制浓度（MIC）测定。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Products and Bioprospecting CHEMISTRY, MEDICINAL-

CiteScore

8.30

自引率

2.10%

发文量

审稿时长

13 weeks

期刊介绍： Natural Products and Bioprospecting serves as an international forum for essential research on natural products and focuses on, but is not limited to, the following aspects: Natural products: isolation and structure elucidation Natural products: synthesis Biological evaluation of biologically active natural products Bioorganic and medicinal chemistry Biosynthesis and microbiological transformation Fermentation and plant tissue cultures Bioprospecting of natural products from natural resources All research articles published in this journal have undergone rigorous peer review. In addition to original research articles, Natural Products and Bioprospecting publishes reviews and short communications, aiming to rapidly disseminate the research results of timely interest, and comprehensive reviews of emerging topics in all the areas of natural products. It is also an open access journal, which provides free access to its articles to anyone, anywhere.