A. Yu. Garanin, D. S. Plevako, O. A. Vasilyeva, A. V. Malek
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引用次数: 0
Abstract
Membrane-bound extracellular nanovesicles (ENVs) are a natural product of the secretory activity of living cells. One of the main biological functions of ENVs is considered to be intercellular transport. The size, stability, possibility of surface modification, and other characteristics indicate the possibility of using ENVs as a drug delivery system. The introduction of “vesicular” drug formulations into practice involves the development of a set of complementary technologies: obtaining ENVs, forming a vesicular dosage form, modifying the vesicular surface in accordance with the therapeutic purpose and the method of administration of the finished product. These aspects are covered in this review based on an analysis of studies devoted to the development of anticancer drugs. The final chapter discusses the stages of development and implementation of vesicular drug delivery systems into clinical practice.
期刊介绍：
Nanobiotechnology Reports publishes interdisciplinary research articles on fundamental aspects of the structure and properties of nanoscale objects and nanomaterials, polymeric and bioorganic molecules, and supramolecular and biohybrid complexes, as well as articles that discuss technologies for their preparation and processing, and practical implementation of products, devices, and nature-like systems based on them. The journal publishes original articles and reviews that meet the highest scientific quality standards in the following areas of science and technology studies: self-organizing structures and nanoassemblies; nanostructures, including nanotubes; functional and structural nanomaterials; polymeric, bioorganic, and hybrid nanomaterials; devices and products based on nanomaterials and nanotechnology; nanobiology and genetics, and omics technologies; nanobiomedicine and nanopharmaceutics; nanoelectronics and neuromorphic computing systems; neurocognitive systems and technologies; nanophotonics; natural science methods in a study of cultural heritage items; metrology, standardization, and monitoring in nanotechnology.
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