A magnetic patch robot with photothermal-activated multi-modality for targeted anti-postoperative adhesion

IF 25.1 1区工程技术 Q1 ENGINEERING, MANUFACTURING

International Journal of Extreme Manufacturing Pub Date : 2025-05-01 DOI:10.1088/2631-7990/add2de

Tanyong Wei, Yang Hu, Ming Yang, Chaoyang Shi, Chengzhi Hu

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引用次数: 8

Abstract

Abstract Adhesive patches offer an effective approach for wound closure, making them highly suitable for biomedical applications. However, conventional patches often face limitations such as dual-sided adhesion, lack of shape adaptability, and limited maneuverability, which restrict their applications in deeper tissues. In this paper, we develop a magnetic patch robot (PatchBot), for targeted Janus adhesion with tissues. The PatchBot features a unique triple-layer structure, with adhesive, shape-morphing, and anti-adhesive layers, each fulfilling roles to support targeted attachment, enable shape transformation, and prevent unwanted adhesion to surrounding tissues. The Janus adhesion of the PatchBot was extensively demonstrated across a variety of tissues. A localized near-infrared (NIR) laser irradiation was used to induce programmable shape transformations. Magnetic actuation of the PatchBot for targeted adhesion was successfully demonstrated in ex vivo porcine stomach tissue. NIR light-activated shape-morphing and multimodal magnetic actuation significantly enhance its maneuverability and adaptability in confined in vivo environments while ensuring the structural integrity of the adhesive surface during deployment. This proof-of-concept study demonstrates the feasibility of using PatchBot for targeted wound adhesion, showing its potential for minimally invasive, precision therapies in complex in vivo environments.

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一种光热激活多模态磁贴机器人，用于靶向抗术后粘连

摘要：贴片为伤口愈合提供了一种有效的方法，使其非常适合生物医学应用。然而，传统的贴片往往面临诸如双面粘连、缺乏形状适应性和有限的可操作性等限制，这限制了它们在深层组织中的应用。在本文中，我们开发了一种磁性贴片机器人（PatchBot），用于针对Janus与组织的粘附。PatchBot具有独特的三层结构，具有粘附层、变形层和抗粘附层，每一层都能发挥作用，支持目标附着，实现形状转换，并防止对周围组织的不必要粘附。PatchBot的双面粘连在多种组织中得到了广泛的证明。采用局部近红外激光照射诱导可编程形状变换。磁驱动PatchBot在离体猪胃组织中成功实现了靶向粘附。近红外光激活的形状变形和多模态磁驱动显着增强了其在受限体内环境中的可操作性和适应性，同时确保了粘合剂表面在部署过程中的结构完整性。这项概念验证研究证明了PatchBot用于靶向伤口粘附的可行性，显示了其在复杂体内环境中微创、精确治疗的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Extreme Manufacturing Engineering-Industrial and Manufacturing Engineering

CiteScore

17.70

自引率

6.10%

发文量

审稿时长

12 weeks

期刊介绍： The International Journal of Extreme Manufacturing (IJEM) focuses on publishing original articles and reviews related to the science and technology of manufacturing functional devices and systems with extreme dimensions and/or extreme functionalities. The journal covers a wide range of topics, from fundamental science to cutting-edge technologies that push the boundaries of currently known theories, methods, scales, environments, and performance. Extreme manufacturing encompasses various aspects such as manufacturing with extremely high energy density, ultrahigh precision, extremely small spatial and temporal scales, extremely intensive fields, and giant systems with extreme complexity and several factors. It encompasses multiple disciplines, including machinery, materials, optics, physics, chemistry, mechanics, and mathematics. The journal is interested in theories, processes, metrology, characterization, equipment, conditions, and system integration in extreme manufacturing. Additionally, it covers materials, structures, and devices with extreme functionalities.

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