Programmable Magnetic Navigation of Gelatin Microrobots Enhances AB4 Delivery to Inflamed Lung Epithelium

IF 2.5 4区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Magnetochemistry Pub Date : 2025-11-01 DOI:10.3390/magnetochemistry11110096

Yue Bu, Jianpeng Xu, Chuanhua Li, Zhixi Li, Yongjing Yu, Ziyong Yue

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引用次数: 0

Abstract

Sepsis-induced acute lung injury (SALI) is characterized by dysregulated inflammation with limited therapeutic options. Although Anemoside B4 (AB4) exhibits anti-inflammatory properties, its clinical application is hindered by poor bioavailability. To address this limitation, we developed magnetically guided gelatin microrobots (MG-AB4) for targeted AB4 delivery. The MG-AB4 system consists of a Fe3O4-loaded gelatin shell for enabling precise magnetic navigation (velocity: 110 μm/s), an AB4 core for rapid drug release which is advantageous for acute inflammatory responses, and surface modifications to enhance cellular uptake. Compared with free AB4, MG-AB4 significantly suppressed key inflammatory cytokines (Interleukin-6 (IL-6), Interleukin-1 beta (IL-1β), Tumor necrosis factor-alpha (TNF-α); p < 0.01), inhibited NF-κB activation (p < 0.01), and improved cell viability in an inflammatory model (p < 0.05). This study demonstrates that magnetically guided AB4 delivery using rapidly releasing microrobots is a promising strategy for SALI treatment, wherein the synergy of targeted delivery and potent anti-inflammatory action may effectively mitigate disease progression.

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凝胶微机器人的可编程磁导航增强AB4对炎症肺上皮的递送

脓毒症引起的急性肺损伤（SALI）的特点是炎症失调，治疗选择有限。虽然Anemoside B4 （AB4）具有抗炎特性，但其生物利用度较差，阻碍了其临床应用。为了解决这一限制，我们开发了用于靶向AB4递送的磁引导明胶微型机器人（MG-AB4）。MG-AB4系统包括一个负载fe3o4的明胶外壳，用于实现精确的磁导航（速度：110 μm/s），一个AB4核心，用于快速释放药物，有利于急性炎症反应，以及表面修饰以增强细胞摄取。与游离AB4相比，MG-AB4显著抑制关键炎症因子(白细胞介素-6 （IL-6）、白细胞介素-1β (IL-1β)、肿瘤坏死因子-α (TNF-α)；p < 0.01)，抑制NF-κB活化（p < 0.01），提高炎症模型细胞活力（p < 0.05）。这项研究表明，使用快速释放的微型机器人进行磁引导AB4递送是SALI治疗的一种很有前途的策略，其中靶向递送和有效的抗炎作用的协同作用可能有效地减缓疾病进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Magnetochemistry Chemistry-Chemistry (miscellaneous)

CiteScore

3.90

自引率

11.10%

发文量

145

审稿时长

11 weeks

期刊介绍： Magnetochemistry (ISSN 2312-7481) is a unique international, scientific open access journal on molecular magnetism, the relationship between chemical structure and magnetism and magnetic materials. Magnetochemistry publishes research articles, short communications and reviews. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.