The customized design and fabrication of microchannels via optically induced dielectrophoresis for particle manipulation

Nanotechnology and Precision Engineering Pub Date : 2025-01-08 DOI:10.1063/10.0034715

Wenhao Wang, Zhizheng Gao, Xian Feng, Xiangyu Teng, Zezheng Qiao, Zhixing Ge, Qun Fan, Wenguang Yang

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引用次数: 1

Abstract

The design and manufacturing of microchannels are crucial aspects of modern micro/nanomanufacturing processes, offering a versatile platform for manipulating and driving micro/nanoparticles or cells. In this study, we propose a method for manufacturing microchannels using optically induced dielectrophoresis technology to induce the polymerization of polyethylene glycol diacrylate solution. To overcome limitations related to the light intensity energy and the size of intact microchannels, we design and manufacture microstructures of various shapes with a height of 4 µm. Additionally, we simulate and analyze the movement of and forces acting on polystyrene (PS) microspheres at different spatial positions within the microchannels. Finally, we successfully demonstrate applications involving the transport of PS microspheres in custom-fabricated microchannels. This novel biocompatible microchannel manufacturing method is simple and non-biotoxic. It provides a new approach for simulating physiological environments in vitro and cultivating and manipulating cells.

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微通道的定制设计和制造，通过光诱导介质电泳用于粒子操作

微通道的设计和制造是现代微/纳米制造工艺的关键方面，为操纵和驱动微/纳米颗粒或细胞提供了一个通用的平台。在本研究中，我们提出了一种利用光诱导介电泳技术来诱导聚乙二醇二丙烯酸酯溶液聚合的微通道制造方法。为了克服与光强能量和完整微通道尺寸相关的限制，我们设计和制造了高度为4 μ m的各种形状的微结构。此外，我们还模拟和分析了聚苯乙烯（PS）微球在微通道内不同空间位置的运动和作用于聚苯乙烯（PS）微球的力。最后，我们成功地演示了PS微球在定制微通道中的传输应用。这种新型的生物相容性微通道制造方法简单且无生物毒性。这为体外模拟生理环境、培养和操纵细胞提供了新的途径。

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