The Triglyceride-Glucose Index is associated with hospital and Intensive Care Unit Mortality in critically ill patients with Acute Coronary Syndrome.

IF 1.7 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Journal of Research in Medical Sciences Pub Date : 2026-01-31 eCollection Date: 2026-01-01 DOI:10.4103/jrms.jrms_511_25

Zihuai Huang, Qianqian Zou, Ya Lin

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Abstract

Background: Acute coronary syndrome (ACS) is one of the leading causes of death, but there is no attention paid to the risk stratification of patients with ACS.

Aims: We evaluated the utility of the triglyceride-glucose (TyG) index in predicting the hospital and intensive care unit (ICU) mortality of critically ill patients with ACS.

Materials and methods: The study patients were collected from the eICU Collaborative Research Database. TyG index was calculated as the ln (fasting glucose level [mg/dL] × triglyceride level [mg/dL]/2). The endpoints were hospital and ICU mortality. The univariate and multivariate logistic regressions and subgroup analysis were used to determine the relationship between the TyG index and two endpoints. The scatter plots, bar graphs and smoothing curves further proved it.

Results: 5237 critically ill patients with ACS were enrolled. The TyG index was obviously higher in nonsurvivors groups than survivors groups. TyG index was significantly associated with hospital mortality in univariate analysis (odds ratio [OR] 1.33, 95% confidence interval [CI] 1.15-1.53, P < 0.001), adjusted model I (OR 1.59, 95% CI 1.36-1.85, P < 0.001) and adjusted model II (OR 2.23, 95% CI 1.50-3.31, P < 0.001). The ICU mortality showed the same trends (OR 1.50, 95% CI 1.26-1.78, OR 1.73, 95% CI 1.45-2.06, OR 2.53, 95% CI 1.59-4.03, P < 0.001). The same trends were observed after stratified by tertiles and quartiles. There were continuous linear relations between the TyG index and hospital and ICU mortality.

Conclusion: TyG index is an independent predictor of ICU and hospital mortality in critically ill patients with ACS.

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甘油三酯-葡萄糖指数与急性冠状动脉综合征危重患者在医院和重症监护病房的死亡率相关

背景：急性冠脉综合征（ACS）是导致死亡的主要原因之一，但ACS患者的危险分层尚未引起重视。目的：我们评估甘油三酯-葡萄糖（TyG）指数在预测ACS危重患者医院和重症监护病房（ICU）死亡率方面的效用。材料和方法：研究患者来自eICU合作研究数据库。TyG指数计算为ln（空腹血糖水平[mg/dL] ×甘油三酯水平[mg/dL]/2）。终点是医院和ICU的死亡率。采用单因素和多因素logistic回归及亚组分析确定TyG指数与两个终点之间的关系。散点图、条形图和平滑曲线进一步证明了这一点。结果：5237例危重ACS患者入组。非幸存者组TyG指数明显高于幸存者组。单因素分析中，TyG指数与医院死亡率显著相关（比值比[OR] 1.33, 95%可信区间[CI] 1.15-1.53, P < 0.001），校正模型I (OR 1.59, 95% CI 1.36-1.85, P < 0.001)，校正模型II （OR 2.23, 95% CI 1.50-3.31, P < 0.001）。ICU死亡率呈现相同趋势（OR 1.50, 95% CI 1.26 ~ 1.78, OR 1.73, 95% CI 1.45 ~ 2.06, OR 2.53, 95% CI 1.59 ~ 4.03, P < 0.001）。按三分位数和四分位数分层后，也观察到同样的趋势。TyG指数与医院和ICU死亡率呈连续线性关系。结论：TyG指数是ACS危重患者ICU和住院死亡率的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Research in Medical Sciences MEDICINE, GENERAL & INTERNAL-

CiteScore

2.60

自引率

6.20%

发文量

审稿时长

3-6 weeks

期刊介绍： Journal of Research in Medical Sciences, a publication of Isfahan University of Medical Sciences, is a peer-reviewed online continuous journal with print on demand compilation of issues published. The journal’s full text is available online at http://www.jmsjournal.net. The journal allows free access (Open Access) to its contents and permits authors to self-archive final accepted version of the articles on any OAI-compliant institutional / subject-based repository.