Elevated gamma spectral event peak power during auditory chirp is associated with neuropsychiatric features in Fragile X syndrome

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI:10.1016/j.clinph.2026.2111713

Yanchen Liu , Peyton Siekierski , Lisa A. De Stefano , Grace Westerkamp , Lauren Ethridge , Elizabeth Blank , Makoto Miyakoshi , Ryan V. Thorpe , Stephanie R. Jones , Craig Erickson , Paul S. Horn , Ernest V. Pedapati

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引用次数: 0

Abstract

Objective

Investigate transient, non-averaged electroencephalography (EEG) signals in the gamma frequency band during an auditory chirp paradigm in individuals with Fragile X syndrome (FXS), a population characterized by elevated background gamma power, and to assess their relationship with clinical features.

Methods

Source-localized EEG responses to auditory chirp stimulus were studied in 36 individuals with FXS and 39 typically developing controls (TDC). Transient high-power gamma-band events were extracted using a thresholding approach. Gamma event properties were compared between groups and correlated with mean EEG features and clinical measures.

Results

In male FXS subjects, gamma event peak power was increased in the temporal source and lacked correlation with inter-trial coherence (ITC). Event rate, duration, and frequency span were similar between groups. Event peak power was positively correlated with obsessive and stereotyped behavior scales.

Conclusions

Peak power of transient gamma events during auditory response is tonically elevated, dissociated from phase synchronization, and associated with neuropsychiatric features in FXS.

Significance

Identifying a tonic elevation of gamma event peak power in FXS during auditory processing suggests altered neural circuit mechanisms underlying aberrant gamma activity. This provides a more direct basis for understanding auditory hypersensitivity, fostering opportunities for back translation and targeted treatment development.

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在脆性X综合征中，听觉啁啾期间伽马谱事件峰值功率升高与神经精神特征相关。

目的：研究脆性X综合征（脆性X综合征，FXS）患者在听觉啁啾模式下的瞬时、非平均脑电图（EEG）信号，并评估其与临床特征的关系。脆性X综合征是一个以背景伽马功率升高为特征的人群。方法：研究了36例FXS患者和39例正常发育对照（TDC）对听觉啁啾刺激的源定位脑电反应。采用阈值法提取瞬态高功率伽马波段事件。比较两组间γ事件的性质，并与平均脑电图特征和临床测量相关联。结果：在男性FXS受试者中，伽马事件峰值功率在时间源上增加，与试验间相干性（ITC）缺乏相关性。事件发生率、持续时间和频率跨度在两组之间相似。事件峰值功率与强迫和刻板行为量表呈正相关。结论：听觉反应中瞬时伽马事件的峰值功率强直性升高，与相同步分离，并与FXS的神经精神特征相关。意义：在听觉加工过程中，FXS中伽马事件峰值功率的强直性升高表明异常伽马活动背后的神经回路机制发生了改变。这为理解听觉超敏症提供了更直接的基础，为反向翻译和有针对性的治疗发展提供了机会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.