[PLGA nanoparticles - bioengineering solutions in medicine and dentistry].

Abstract

Presented to analyze the accumulated scientific information on the possibilities and use in dentistry of poly-lactic acid glycolic acid (PLGA) nanoparticles, which act as carriers of various drugs, ensuring their delivery to the foci of inflammation, tumor processes or into the depths of the microbial biofilm. Such nanostructured complexes make it possible to increase the absorption of general drugs through the oral mucosa, prevent the formation of microbial biofilms, and prevent and treat dental caries, its complications, and periodontal inflammatory diseases. Targeted delivery and targeted use of PLGA-based dosage forms prevents the development of resistance, allergic reactions, desquamation of the epithelium, staining of plaque and fillings, as well as other resorptive effects of known antimicrobial agents. The synthesis of PLGA is not very difficult, and technologies based on the use of these polymer nanoparticles can significantly help the dentist.