The impact of injection site on the pharmacokinetics of danofloxacin in Pekin ducks (Anas platyrhynchos domestica)

IF 1.8 3区农林科学 Q1 VETERINARY SCIENCES

Research in veterinary science Pub Date : 2026-05-01 Epub Date: 2026-02-24 DOI:10.1016/j.rvsc.2026.106122

Kamil Uney , Orhan Corum , Duygu Durna Corum , Devran Coskun , Pedro Marin , Mario Giorgi , Amnart Poapolathep , Saranya Poapolathep , Tugce Karaahmetli , Enver Yazar , Muammer Elmas

{"title":"The impact of injection site on the pharmacokinetics of danofloxacin in Pekin ducks (Anas platyrhynchos domestica)","authors":"Kamil Uney , Orhan Corum , Duygu Durna Corum , Devran Coskun , Pedro Marin , Mario Giorgi , Amnart Poapolathep , Saranya Poapolathep , Tugce Karaahmetli , Enver Yazar , Muammer Elmas","doi":"10.1016/j.rvsc.2026.106122","DOIUrl":null,"url":null,"abstract":"<div><div>The purpose of this study was to investigate the influence of injection site on danofloxacin pharmacokinetics in Pekin ducks. Thirty-two male Peking ducks were divided into 4 equal groups as intravenous (IV), pectoral muscles (IMP), thigh muscles (IMT) and subcutaneous (SC). Danofloxacin was administered to all groups at a dose of 10 mg/kg. Plasma concentrations of danofloxacin were quantified by HPLC-UV. The volume of distribution at steady state and total clearance values of danofloxacin after IV injections in ducks were 4.43 L/kg and 0.42 L/h/kg, respectively. The terminal elimination half-life (t<sub>1/2ʎz</sub>), area under the concentration-versus time curve (AUC)<sub>0-last</sub>, and peak plasma concentration (C<sub>max</sub>) were similar after SC and IMP injections of danofloxacin. However, t<sub>1/2ʎz</sub> was shorter and AUC<sub>0-last</sub> and C<sub>max</sub> were lower in the IMT group compared to the IMP group. The bioavailability was lower in the IMT group than in the IMP and SC groups. Danofloxacin exhibited similar pharmacokinetic profiles after SC and IMP injection into Pekin ducks. In the IMT group, pharmacokinetics altered significantly, resulting in reduced body exposure and residence time of danofloxacin. Optimizing the injection site to subcutaneous or pectoral muscle routes may improve danofloxacin's therapeutic efficacy in Pekin ducks, while caution should be applied with thigh muscle injections due to reduced bioavailability and systemic exposure.</div></div>","PeriodicalId":21083,"journal":{"name":"Research in veterinary science","volume":"203 ","pages":"Article 106122"},"PeriodicalIF":1.8000,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Research in veterinary science","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0034528826000743","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2026/2/24 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

The purpose of this study was to investigate the influence of injection site on danofloxacin pharmacokinetics in Pekin ducks. Thirty-two male Peking ducks were divided into 4 equal groups as intravenous (IV), pectoral muscles (IMP), thigh muscles (IMT) and subcutaneous (SC). Danofloxacin was administered to all groups at a dose of 10 mg/kg. Plasma concentrations of danofloxacin were quantified by HPLC-UV. The volume of distribution at steady state and total clearance values of danofloxacin after IV injections in ducks were 4.43 L/kg and 0.42 L/h/kg, respectively. The terminal elimination half-life (t_1/2ʎz), area under the concentration-versus time curve (AUC)_0-last, and peak plasma concentration (C_max) were similar after SC and IMP injections of danofloxacin. However, t_1/2ʎz was shorter and AUC_0-last and C_max were lower in the IMT group compared to the IMP group. The bioavailability was lower in the IMT group than in the IMP and SC groups. Danofloxacin exhibited similar pharmacokinetic profiles after SC and IMP injection into Pekin ducks. In the IMT group, pharmacokinetics altered significantly, resulting in reduced body exposure and residence time of danofloxacin. Optimizing the injection site to subcutaneous or pectoral muscle routes may improve danofloxacin's therapeutic efficacy in Pekin ducks, while caution should be applied with thigh muscle injections due to reduced bioavailability and systemic exposure.

查看原文本刊更多论文

注射部位对丹诺沙星在北京鸭体内药动学的影响。

研究注射部位对丹诺沙星在北京鸭体内药动学的影响。将32只雄性北京鸭分为静脉注射组（IV）、胸肌组（IMP）、大腿肌组（IMT）和皮下注射组（SC）。各组均以10 mg/kg的剂量给予达诺沙星。采用高效液相色谱-紫外分光光度法测定血药浓度。鸭体内静脉注射达诺沙星的稳态分布体积和总清除率分别为4.43 L/kg和0.42 L/h/kg。SC和IMP注射达诺沙星的终末消除半衰期（t1/2）、浓度-时间曲线下面积（AUC）0-last和血药峰浓度（Cmax）相似。与IMP组相比，IMT组t1/2 lz较短，AUC0-last和Cmax较低。IMT组的生物利用度低于IMP和SC组。注射SC和IMP后，达诺沙星在北京鸭体内表现出相似的药动学特征。在IMT组，药代动力学发生显著改变，导致丹诺沙星体内暴露和停留时间减少。优化注射部位至皮下或胸肌途径可提高丹诺沙星对北京鸭的治疗效果，但大腿肌肉注射由于生物利用度降低和全身暴露，应谨慎使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Research in veterinary science 农林科学-兽医学

CiteScore

4.40

自引率

4.20%

发文量

312

审稿时长

75 days

期刊介绍： Research in Veterinary Science is an International multi-disciplinary journal publishing original articles, reviews and short communications of a high scientific and ethical standard in all aspects of veterinary and biomedical research. The primary aim of the journal is to inform veterinary and biomedical scientists of significant advances in veterinary and related research through prompt publication and dissemination. Secondly, the journal aims to provide a general multi-disciplinary forum for discussion and debate of news and issues concerning veterinary science. Thirdly, to promote the dissemination of knowledge to a broader range of professions, globally. High quality papers on all species of animals are considered, particularly those considered to be of high scientific importance and originality, and with interdisciplinary interest. The journal encourages papers providing results that have clear implications for understanding disease pathogenesis and for the development of control measures or treatments, as well as those dealing with a comparative biomedical approach, which represents a substantial improvement to animal and human health. Studies without a robust scientific hypothesis or that are preliminary, or of weak originality, as well as negative results, are not appropriate for the journal. Furthermore, observational approaches, case studies or field reports lacking an advancement in general knowledge do not fall within the scope of the journal.