Magnetoencephalographic Signatures of Facial Emotion Processing in Schizophrenia and Major Depressive Disorder: A Systematic Review.

IF 3.1 4区心理学 Q3 NEUROSCIENCES

Neuropsychobiology Pub Date : 2026-02-26 DOI:10.1159/000550903

Mauro Scala, Juergen Dukart, Giuseppe De Simone, Giuseppe Fanelli, Rocío Arroyo Iturra, Sara Bordignon, Chiara Fabbri, Alessandro Serretti

{"title":"Magnetoencephalographic Signatures of Facial Emotion Processing in Schizophrenia and Major Depressive Disorder: A Systematic Review.","authors":"Mauro Scala, Juergen Dukart, Giuseppe De Simone, Giuseppe Fanelli, Rocío Arroyo Iturra, Sara Bordignon, Chiara Fabbri, Alessandro Serretti","doi":"10.1159/000550903","DOIUrl":null,"url":null,"abstract":"Introduction: Social withdrawal is a frequent marker of functional decline in schizophrenia, Alzheimer's disease (AD), and major depressive disorder (MDD), and is associated with deficits in facial-emotion recognition (FER). Magnetoencephalography (MEG) captures neuronal activity at millisecond resolution, enabling the assessment of fast oscillatory dynamics and functional connectivity during FER. This systematic review compares MEG responses during implicit and explicit FER tasks in adults with schizophrenia, AD, and MDD to identify possible transdiagnostic and disorder-specific alterations. However, no eligible studies were identified for AD.Methods: Following PRISMA guidelines, PubMed, Web of Science, and CINAHL were systematically searched from inception to February 2025 for MEG studies comparing adults with schizophrenia, AD, or MDD with healthy controls during implicit (i.e., passive viewing) or explicit (i.e., labeling) FER tasks.Results: Eighteen studies met inclusion criteria (four schizophrenia, 14 MDD, none in AD). Schizophrenia and MDD showed transdiagnostic MEG patterns across disorder-specific studies, including early temporal-cortical hyperactivation (50-150 ms) during implicit FER and early amygdala hyper-reactivity (within 100 ms) followed by prefrontal hypo-recruitment (100-500 ms) during explicit FER, with disrupted cortico-limbic connectivity. Schizophrenia was associated with specific increases in theta-gamma coupling and unidirectional visual-limbic-prefrontal connectivity during explicit FER. MDD showed a shift from early gamma hyper-synchrony (50-150 ms) to late beta/gamma hypo-synchrony (250-500 ms), with reduced fronto-limbic and fusiform-amygdala coupling.Conclusions: MEG reveals a transdiagnostic signature of FER dysfunction that may be linked to social withdrawal and disorder-specific oscillatory patterns that may inform targeted neuromodulation.","PeriodicalId":19239,"journal":{"name":"Neuropsychobiology","volume":" ","pages":"1-21"},"PeriodicalIF":3.1000,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neuropsychobiology","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1159/000550903","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Social withdrawal is a frequent marker of functional decline in schizophrenia, Alzheimer's disease (AD), and major depressive disorder (MDD), and is associated with deficits in facial-emotion recognition (FER). Magnetoencephalography (MEG) captures neuronal activity at millisecond resolution, enabling the assessment of fast oscillatory dynamics and functional connectivity during FER. This systematic review compares MEG responses during implicit and explicit FER tasks in adults with schizophrenia, AD, and MDD to identify possible transdiagnostic and disorder-specific alterations. However, no eligible studies were identified for AD.

Methods: Following PRISMA guidelines, PubMed, Web of Science, and CINAHL were systematically searched from inception to February 2025 for MEG studies comparing adults with schizophrenia, AD, or MDD with healthy controls during implicit (i.e., passive viewing) or explicit (i.e., labeling) FER tasks.

Results: Eighteen studies met inclusion criteria (four schizophrenia, 14 MDD, none in AD). Schizophrenia and MDD showed transdiagnostic MEG patterns across disorder-specific studies, including early temporal-cortical hyperactivation (50-150 ms) during implicit FER and early amygdala hyper-reactivity (within 100 ms) followed by prefrontal hypo-recruitment (100-500 ms) during explicit FER, with disrupted cortico-limbic connectivity. Schizophrenia was associated with specific increases in theta-gamma coupling and unidirectional visual-limbic-prefrontal connectivity during explicit FER. MDD showed a shift from early gamma hyper-synchrony (50-150 ms) to late beta/gamma hypo-synchrony (250-500 ms), with reduced fronto-limbic and fusiform-amygdala coupling.

Conclusions: MEG reveals a transdiagnostic signature of FER dysfunction that may be linked to social withdrawal and disorder-specific oscillatory patterns that may inform targeted neuromodulation.

查看原文本刊更多论文

精神分裂症和重度抑郁症患者面部情绪处理的脑磁图特征：一项系统综述。

社交退缩是精神分裂症、阿尔茨海默病（AD）和重度抑郁症（MDD）功能下降的常见标志，并与面部情绪识别（FER）缺陷有关。脑磁图（MEG）以毫秒级的分辨率捕获神经元活动，从而能够评估FER期间的快速振荡动力学和功能连接。本系统综述比较了成人精神分裂症、阿尔茨海默病和重度抑郁症患者在隐性和显性FER任务中的脑磁图反应，以确定可能的跨诊断和疾病特异性改变。然而，没有合适的研究被确定为AD。方法：遵循PRISMA指南，PubMed、Web of Science和CINAHL系统地检索了从成立到2025年2月，在隐性（即被动观看）或显性（即标记）FER任务中比较精神分裂症、AD或MDD成人与健康对照的MEG研究。结果：18项研究符合纳入标准（4项精神分裂症，14项重度抑郁症，无AD）。精神分裂症和重度抑郁症在疾病特异性研究中显示出跨诊断的脑磁图模式，包括隐式脑磁反应期间早期颞皮质过度激活（50-150毫秒）和早期杏仁核过度反应（100毫秒内），随后是显式脑磁反应期间前额叶低招募（100-500毫秒），皮质-边缘连接中断。精神分裂症与外显性脑电刺激期间theta-gamma偶联和单向视觉-边缘-前额叶连通性的特异性增加有关。MDD表现出从早期伽马超同步（50-150 ms）到晚期β /伽马低同步（250-500 ms）的转变，前额边缘和梭状体-杏仁核耦合减少。结论：MEG揭示了FER功能障碍的跨诊断特征，可能与社交退缩和障碍特异性振荡模式有关，可能为靶向神经调节提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuropsychobiology 医学-精神病学

CiteScore

7.20

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： The biological approach to mental disorders continues to yield innovative findings of clinical importance, particularly if methodologies are combined. This journal collects high quality empirical studies from various experimental and clinical approaches in the fields of Biological Psychiatry, Biological Psychology and Neuropsychology. It features original, clinical and basic research in the fields of neurophysiology and functional imaging, neuropharmacology and neurochemistry, neuroendocrinology and neuroimmunology, genetics and their relationships with normal psychology and psychopathology. In addition, the reader will find studies on animal models of mental disorders and therapeutic interventions, and pharmacoelectroencephalographic studies. Regular reviews report new methodologic approaches, and selected case reports provide hints for future research. ''Neuropsychobiology'' is a complete record of strategies and methodologies employed to study the biological basis of mental functions including their interactions with psychological and social factors.