Research on Obesity: A Quarter-Century Experience from the Tehran Lipid and Glucose Study.

IF 1.9 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2026-01-31 eCollection Date: 2026-04-30 DOI:10.5812/ijem-168110

Sara Sadeghi, Behnaz Abiri, Farhad Hosseinpanah, Majid Valizadeh, Fereidoun Azizi, Maryam Mahdavi, Maryam Barzin

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Abstract

Context: This paper aims to synthesize a quarter-century of research on obesity from the Tehran Lipid and Glucose Study (TLGS), a large prospective population-based cohort.

Evidence acquisition: A comprehensive literature search identified original studies from the TLGS investigating obesity indices, body composition, obesity phenotypes, and their associations with cardiometabolic outcomes.

Results: Tehran Lipid and Glucose Study findings demonstrate alarming increases in the prevalence and incidence of general and abdominal obesity among Tehranian adults and children. The studies have established population-specific anthropometric cut-offs, revealed the complex associations of various obesity phenotypes with type 2 diabetes, cardiovascular disease, and chronic kidney disease, and highlighted the critical role of metabolic health over weight status alone.

Conclusions: This substantial body of evidence provides crucial insights for crafting effective public health strategies and future research in transitioning populations.

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肥胖研究：德黑兰脂质和葡萄糖研究的四分之一世纪经验。

背景：本文旨在综合德黑兰脂质和葡萄糖研究（TLGS）四分之一世纪以来的肥胖研究，这是一项大型前瞻性人群队列研究。证据获取：全面的文献检索确定了TLGS的原始研究，调查肥胖指数、身体成分、肥胖表型及其与心脏代谢结果的关系。结果：德黑兰脂质和葡萄糖研究结果表明，德黑兰成人和儿童中一般肥胖和腹部肥胖的患病率和发病率惊人地增加。这些研究建立了人群特异性的人体测量截断值，揭示了各种肥胖表型与2型糖尿病、心血管疾病和慢性肾脏疾病的复杂关联，并强调了代谢健康在体重状态中的关键作用。结论：这一大量证据为制定有效的公共卫生战略和未来在过渡人群中的研究提供了至关重要的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.