Development of a bioactive hydroxyapatite concentration gradient double hydroxyapatite/titanium dioxide coating on TiO₂ core block bone.

IF 1.8 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Dental materials journal Pub Date : 2026-03-29 Epub Date: 2026-03-25 DOI:10.4012/dmj.2025-222

Sang-Hyun Cho, Min-Yong Lee, Ji-Eun Kim, Jae-Sung Kwon

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引用次数: 0

Abstract

There is an increasing demand for bone graft procedures to create sufficient bone volume for implant fixture placement. Among various techniques, block bone grafting is considered a favorable option for both horizontal and vertical augmentation. To meet the required physical and biological characteristics, a novel hydroxyapatite (HA)-coated titanium dioxide (TiO₂) core block bone was developed in this study. The coating layer was designed with an HA concentration gradient to achieve superior compressive strength and wear resistance. The concentration gradient was confirmed by scanning electron microscopy/energy-dispersed X-ray spectroscopy, and coating stability was demonstrated through scratch testing. Furthermore, alizarin red S staining revealed that the HA gradient layer retained bone formation compared to a single-layer HA coating. Taken together, the developed doubled-layered HA gradient TiO₂ block bone shows strong potential as a substitute for conventional block bone grafts.

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生物活性羟基磷灰石浓度梯度双羟基磷灰石/二氧化钛涂层的研制。

有越来越多的需求骨移植程序，以创造足够的骨容量种植固定放置。在各种技术中，块骨移植被认为是水平和垂直增强的有利选择。为了满足所需的物理和生物学特性，本研究开发了一种新型羟基磷灰石（HA）涂层二氧化钛（TiO2）核心块骨。涂层采用HA浓度梯度设计，具有优异的抗压强度和耐磨性。通过扫描电镜/能量分散x射线能谱法确定了涂层的浓度梯度，并通过划痕测试验证了涂层的稳定性。此外，茜素红S染色显示，与单层HA涂层相比，HA梯度层保留了骨形成。综上所述，所开发的双层HA梯度TiO2块骨作为传统块骨移植物的替代品具有很强的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dental materials journal 医学-材料科学：生物材料

CiteScore

4.60

自引率

4.00%

发文量

102

审稿时长

3 months

期刊介绍： Dental Materials Journal is a peer review journal published by the Japanese Society for Dental Materials and Devises aiming to introduce the progress of the basic and applied sciences in dental materials and biomaterials. The dental materials-related clinical science and instrumental technologies are also within the scope of this journal. The materials dealt include synthetic polymers, ceramics, metals and tissue-derived biomaterials. Forefront dental materials and biomaterials used in developing filed, such as tissue engineering, bioengineering and artificial intelligence, are positively considered for the review as well. Recent acceptance rate of the submitted manuscript in the journal is around 30%.