Clinical characteristics of hospitalized patients with hepatitis E virus infection in Poland: a multi-centre retrospective study

IF 2.5 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in medical sciences Pub Date : 2026-03-01 Epub Date: 2026-02-24 DOI:10.1016/j.advms.2026.02.003

Anna Parfieniuk-Kowerda , Jerzy Jaroszewicz , Piotr Grabarczyk , Dorota Zarebska-Michaluk , Katarzyna Sikorska , Anna Piekarska , Aleksandra Berkan-Kawinska , Dorota Kozielewicz , Małgorzata Pawlowska , Monika Pazgan-Simon , Barbara Sobala-Szczygiel , Piotr Zielinski , Andrzej Rydzewski , Agnieszka Serwacka , Krzysztof Tomasiewicz , Bozena Katarzyna Budziszewska , Robert Flisiak

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引用次数: 0

Abstract

Purpose

The burden of hepatitis E virus (HEV) infections in Poland is highly underestimated and in contrast with high anti-HEV IgG seroprevalence in Polish population. This is the first publication addressing the issues of HEV infections in Poland as well as surveillance and reporting problems referring to this particular disease.

Patients and methods

In this retrospective study we analysed 61 HEV cases referred to and diagnosed in 10 leading centres in Poland.

Results

Males constituted 70.5% of the study group, with equal distribution of cases below and over 50 years of age. Comorbidities were reported in 73.8% of this group. Of major concern was the high frequency of reported complications and clinical outcomes: 3 cases of acute liver failure (ALF) with 1 resulting in orthotopic liver transplantation (OLTx), 1 case of renal insufficiency, 3 cases of neuralgic amyotrophy, 8 cases of thromocytopaenia, and 4 cases of chronic hepatitis E.

Conclusions

The HEV infections in Poland are considerably underestimated, which results both from the lack of awareness of general practitioners and limited access to HEV diagnostics, particularly in primary and secondary care medical facilities in Poland.

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波兰戊型肝炎病毒感染住院患者的临床特征：一项多中心回顾性研究

目的：波兰戊型肝炎病毒（HEV）感染的负担被严重低估，与波兰人群中高抗HEV IgG血清阳性率相反。这是第一份针对波兰HEV感染问题以及与这一特殊疾病有关的监测和报告问题的出版物。患者和方法：在这项回顾性研究中，我们分析了在波兰10个主要中心转诊和诊断的61例HEV病例。结果：男性占研究组的70.5%，50岁以下和50岁以上的病例分布均匀。该组中有73.8%的患者报告了合并症。主要关注的是报告的高频率并发症和临床结果：3例急性肝衰竭（ALF）， 1例导致原位肝移植（OLTx）， 1例肾功能不全，3例神经性肌萎缩，8例血小板减少症，4例慢性戊型肝炎。波兰的HEV感染被大大低估了，这是由于全科医生缺乏认识，以及获得HEV诊断的机会有限，特别是在波兰的初级和二级保健医疗机构。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in medical sciences 医学-医学：研究与实验

CiteScore

5.00

自引率

0.00%

发文量

审稿时长

25 days

期刊介绍： Advances in Medical Sciences is an international, peer-reviewed journal that welcomes original research articles and reviews on current advances in life sciences, preclinical and clinical medicine, and related disciplines. The Journal’s primary aim is to make every effort to contribute to progress in medical sciences. The strive is to bridge laboratory and clinical settings with cutting edge research findings and new developments. Advances in Medical Sciences publishes articles which bring novel insights into diagnostic and molecular imaging, offering essential prior knowledge for diagnosis and treatment indispensable in all areas of medical sciences. It also publishes articles on pathological sciences giving foundation knowledge on the overall study of human diseases. Through its publications Advances in Medical Sciences also stresses the importance of pharmaceutical sciences as a rapidly and ever expanding area of research on drug design, development, action and evaluation contributing significantly to a variety of scientific disciplines. The journal welcomes submissions from the following disciplines: General and internal medicine, Cancer research, Genetics, Endocrinology, Gastroenterology, Cardiology and Cardiovascular Medicine, Immunology and Allergy, Pathology and Forensic Medicine, Cell and molecular Biology, Haematology, Biochemistry, Clinical and Experimental Pathology.